Proteinuria Is Still Useful for the Screening and Diagnosis of Overt Diabetic Nephropathy
| Autor: | João Carlos de Oliveira, M J de Azevedo, J L Gross, Themis Zelmanovitz |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Urinary system Urology Urine Sensitivity and Specificity Nephropathy Excretion chemistry.chemical_compound Diabetes mellitus Internal medicine Internal Medicine medicine Albuminuria Humans Mass Screening Diabetic Nephropathies Aged Aged 80 and over Advanced and Specialized Nursing Creatinine Sulfosalicylic acid Proteinuria business.industry Middle Aged medicine.disease Diabetes Mellitus Type 1 Endocrinology Diabetes Mellitus Type 2 ROC Curve chemistry Female medicine.symptom business |
| Zdroj: | Diabetes Care. 21:1076-1079 |
| ISSN: | 1935-5548 0149-5992 |
| Popis: | OBJECTIVE To assess the performance of urinary total protein measurements in timed 24-h urine collection (24-h UP) and in a diurnal random urine specimen (RUS) for the screening and diagnosis of overt diabetic nephropathy. RESEARCH DESIGN AND METHODS A total of 167 diabetic patients (20 type 1 and 147 type 2 diabetic patients; 78 women and 89 men), aged 20–84 years, collected 217 timed 24-h urine specimens. Albumin was measured by immunoturbidimetry, total protein by sulfosalicylic acid technique, and creatinine by Jaffe's method. According to the timed 24-h urinary albumin excretion rate (UAER), samples were divided into three groups: normoalbuminuric (NORMO) (UAER RESULTS Spearman's coefficient of correlation of 24-h UAER versus 24-h UP was 0.95 (P < 0.001), and of 24-h UAER versus UPC and UPCR were 0.77 and 0.72, respectively (P < 0.001). The calculated areas (±SEM) under the ROC curve for the diagnosis of overt diabetic nephropathy were 0.9987 ± 0.001 for 24-h UP, 0.9926 ± 0.006 for UPC, and 0.9751 ± 0.014 for UPCR. In the ROC curves, the first points with 100% sensitivity were 541 mg (95.7% specificity) for 24-h UP, 431 mg/1 (92.9% specificity) for UPC, and 0.2 (76.2% specificity) for UPCR. CONCLUSIONS Measurements of proteinuria presented almost perfect accuracy for the screening and diagnosis of overt diabetic nephropathy. Protein measurement in spot urine is a reliable and simple method for the screening and diagnosis of overt diabetic nephropathy. |
| Databáze: | OpenAIRE |
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