Nucleolar proteins that bind NLSs: a role in nuclear import or ribosome biogenesis?

Autor:	Zhixiong Xue, Teri Mélèse
Rok vydání:	1994
Předmět:	Ribosomal protein Nucleolar Proteins Ribosome biogenesis Cell Biology Nuclear transport Casein kinase 2 Biology Nuclear localization sequence Cell biology
Zdroj:	Trends in Cell Biology. 4:414-417
ISSN:	0962-8924
DOI:	10.1016/0962-8924(94)90095-7
Popis:	In a search for proteins that bind nuclear localization sequences (NLSs), a number of nucleolar proteins with diverse functions were found. It is thought that the assay fortuitously uncovered a novel domain that mediates the interaction between these nucleolar proteins and ribosomal proteins containing NLS-like sequences. The domain is highly acidic and contains a number of serines forming putative casein kinase II sites. Here, we propose a model in which the nucleolar proteins catalyse the assembly of ribosomal proteins with pre-rRNA.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::824894d65c954a9bf71be5e85454e1a1 https://doi.org/10.1016/0962-8924(94)90095-7 Zobrazit plný text záznamu