Vasculitis and Breast Cancer: Mind the Hint
| Autor: | Salomão Fernandes, Miguel Esperança-Martins, Vasco Evangelista, Raquel Almeida |
|---|---|
| Přispěvatelé: | Repositório da Universidade de Lisboa |
| Rok vydání: | 2021 |
| Předmět: |
Pathology
medicine.medical_specialty Diffuse alveolar haemorrhage business.industry medicine.medical_treatment Case Report Plasmapheresis Cytoplasmic antibody Ductal carcinoma lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease lcsh:RC254-282 Therapeutic approach Breast cancer Oncology Paraneoplastic vasculitis Medicine skin and connective tissue diseases business Vasculitis Adverse effect |
| Zdroj: | Case Reports in Oncology Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP Case Reports in Oncology, Vol 14, Iss 1, Pp 550-560 (2021) |
| ISSN: | 1662-6575 |
| DOI: | 10.1159/000514729 |
| Popis: | © 2021 The Author(s). Published by S. Karger AG, Basel. This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC). Usage and distribution for commercial purposes requires written permission. Diffuse alveolar haemorrhage related to an anti-neutrophil cytoplasmic antibody (ANCA)-associated small vessel vasculitis is an extremely rare form of presentation of breast cancer. Here we report the case of a 77-year-old woman with a histological diagnosis of a papillary ductal carcinoma of the breast presenting with a diffuse alveolar haemorrhage secondary to a perinuclear ANCA-associated vasculitis. To our knowledge, this is the first case ever reported of a diffuse alveolar haemorrhage related to an ANCA-associated small vessel vasculitis as a form of presentation of breast cancer. The therapeutic approach of this paraneoplastic vasculitis included the use of corticosteroids and plasmapheresis, a very useful technique to remove endothelial aggressors (circulating antibodies) as a strategy to earn time for a proper therapeutic decision specifically directed for disease modification, but that can also be associated with several severe adverse effects, which are illustrated in our case. |
| Databáze: | OpenAIRE |
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