Effect of lipemia on implantation of a rabbit carcinoma
| Autor: | Robert M. O'Neal, Atsuo Mikata, Hideshige Imai |
|---|---|
| Rok vydání: | 1962 |
| Předmět: |
medicine.medical_treatment
Metastasis formation digestive oral and skin physiology Clinical Biochemistry food and beverages Hyperlipidemias Rabbit (nuclear engineering) Biology medicine.disease Lipids Pathology and Forensic Medicine Andrology Coagulation Biochemistry Cancer cell Fibrinolysis medicine Carcinoma Animals Humans Rabbits Sugar Molecular Biology Corn oil |
| Zdroj: | Experimental and Molecular Pathology. 1:37-43 |
| ISSN: | 0014-4800 |
| DOI: | 10.1016/0014-4800(62)90006-0 |
| Popis: | Three groups of rabbits were given feedings of butter, corn oil, or isocaloric sugar solution, and 4 hours after the feeding cancer cells (VX2 carcinoma) were injected intravenously. Within 30 minutes thereafter, the tube-feedings were repeated. Lungs were harvested 4 weeks later and grossly visible tumor nodules were counted. Results revealed significantly larger numbers of tumor nodules in rabbits of the butter-group than in the sugar-group. The corn oil-group had numbers of tumor nodules intermediate in respect to the other two groups. This suggests that lipemia existing at the time of tumor dissemination favors metastasis formation, possibly through an enhancing effect on coagulation and/or inhibition of fibrinolysis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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