Lack of Magainin-Like Activity in Human Cervical Tissue
| Autor: | David F. Archer, George L. Wright, Joseph Kilianski, Kathy Newhall, Keith A. Hansen, Richard J. Stock |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Pathology
medicine.medical_specialty Submandibular Gland Immunology Cervix Uteri Xenopus Proteins Magainins Xenopus laevis chemistry.chemical_compound Anti-Infective Agents Antigen Internal medicine medicine Animals Humans Immunology and Allergy Cervix Skin Innate immune system biology Magainin Obstetrics and Gynecology Submandibular gland Anti-Bacterial Agents Endocrinology medicine.anatomical_structure Reproductive Medicine chemistry Polyclonal antibodies biology.protein Immunohistochemistry Female Rabbits Antibody Peptides Biomarkers Antimicrobial Cationic Peptides |
| Zdroj: | American Journal of Reproductive Immunology. 33:481-484 |
| ISSN: | 1046-7408 |
| DOI: | 10.1111/j.1600-0897.1995.tb00910.x |
| Popis: | PROBLEM : The cervix plays an integral role in innate immunity of the human reproductive tract. Magainins are antimicrobial and spermicidal peptides recently described in human submandibular glands. We investigated the human cervix for magainin-like peptides. METHOD : Histologic sections of frozen and paraffin embedded cervical tissue from nine subjects were separately incubated with two rabbit, polyclonal, anti-magainin antibodies (CB-2 and CB-7) to investigate for magainin-like activity in the human cervix. RESULTS : There was no specific staining of cervical columnar cells within the endocervical canal or in the endocervical crypts. Magainin-like immunoreactivity in the human submandibular gland confirmed previous observations. CONCLUSION : Antigen related to magainin-like peptides were not discovered in the human cervix. |
| Databáze: | OpenAIRE |
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