Effects of traumatic brain injury on cognitive functioning and cerebral metabolites in HIV-infected individuals

Autor:	Kenny Lin, Michael J Taylor, Robert Heaton, Donald Franklin, Terry Jernigan, Christine Fennema-Notestine, Allen McCutchan, J Hampton Atkinson, Ronald J Ellis, Justin McArthur, Susan Morgello, David Simpson, Ann C Collier, Christina Marra, Benjamin Gelman, David Clifford, Igor Grant, null for the CHARTER group
Rok vydání:	2011
Předmět:	Male Magnetic Resonance Spectroscopy 6.6 Psychological and behavioural HIV Infections Neuropsychological Tests HIV-associated neurocognitive disorder Executive Function N-acetylaspartate 0302 clinical medicine Psychology 030212 general & internal medicine Pediatric medicine.diagnostic_test Depression Cognitive disorder Head injury virus diseases Experimental Psychology Injuries and accidents Neuropsychological test Middle Aged Childhood Injury Neuropsychological performance 3. Good health Clinical Psychology Mental Health Infectious Diseases Memory Short-Term Neurology Neurological HIV/AIDS Female Cognitive Sciences Research Article Adult medicine.medical_specialty Physical Injury - Accidents and Adverse Effects Substance-Related Disorders Traumatic brain injury Traumatic Brain Injury (TBI) 03 medical and health sciences HIV associated neurocognitive disorder Acquired immunodeficiency syndrome (AIDS) Clinical Research Memory Internal medicine Behavioral and Social Science CHARTER group Acquired Cognitive Impairment medicine Humans Psychiatry Traumatic Head and Spine Injury Psychiatric Status Rating Scales Aspartic Acid Working memory Neurosciences Evaluation of treatments and therapeutic interventions medicine.disease Brain Disorders nervous system diseases Short-Term nervous system Brain Injuries Neurology (clinical) Cognition Disorders Neurocognitive 030217 neurology & neurosurgery
Zdroj:	Journal of clinical and experimental neuropsychology, vol 33, iss 3 Journal of Clinical and Experimental Neuropsychology
ISSN:	1744-411X 1380-3395
DOI:	10.1080/13803395.2010.518140
Popis:	We explored the possible augmenting effect of traumatic brain injury (TBI) history on HIV (human immunodeficiency virus) associated neurocognitive complications. HIV-infected participants with self-reported history of definite TBI were compared to HIV patients without TBI history. Groups were equated for relevant demographic and HIV-associated characteristics. The TBI group evidenced significantly greater deficits in executive functioning and working memory. N-acetylaspartate, a putative marker of neuronal integrity, was significantly lower in the frontal gray matter and basal ganglia brain regions of the TBI group. Together, these results suggest an additional brain impact of TBI over that from HIV alone. One clinical implication is that HIV patients with TBI history may need to be monitored more closely for increased risk of HIV-associated neurocognitive disorder signs or symptoms.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82432b7f0dc5ad9a8afa6c6ff616690e https://doi.org/10.1080/13803395.2010.518140 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.