Proteinuria, 99mTc-DTPA Scintigraphy, Creatinine-, Cystatin- and Combined-Based Equations in the Assessment of Chronic Kidney Disease
| Autor: | Alexis Muryan, Mirta Alonso, Hernán Trimarchi, Agostina Toscano, Mariano Forrester, Vanesa Pomeranz, Mariana Dicugno, Diana Martino, Alejandra Karl, Pablo Young, Fernando Lombi, Clara Fitzsimons, María S. Raña |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Creatinine Proteinuria Article Subject medicine.diagnostic_test business.industry 99mtc dtpa Urology Renal function Scintigraphy urologic and male genital diseases female genital diseases and pregnancy complications chemistry.chemical_compound Endocrinology chemistry Internal medicine medicine Cystatin medicine.symptom business Research Article |
| Zdroj: | ISRN Nephrology |
| ISSN: | 2314-405X |
| Popis: | Background. Precise estimation of the glomerular filtration rate (GFR) and the identification of markers of progression are important. We compared creatinine, cystatin, and combined CKD-EPI equations with Tc-DTPA99m scintigraphy to measure GFR and proteinuria as markers of progression. Methods. Cross-sectional, observational study including 300 subjects. CKD was classified by Tc-DTPA99m scintigraphy. Determinations. Creatinine, 24-hour creatinine clearance, cystatin, Hoek formula, and creatinine, cystatin, and combined CKD-EPI equations. Results. In the global assessment, creatinine CKD-EPI and combined CKD-EPI equations yielded the highest correlations with Tc-DTPA99m: ρ = 0.839, P<0.0001 and ρ = 0.831, P<0.0001. Intergroup analysis versus Tc-DTPA99m: control G, creatinine clearance ρ = 0.414, P = 0.013; G3, combined CKD-EPI ρ = 0.5317, P<0.0001; G4, Hoek ρ = 0.618, P<0.0001, combined CKD-EPI ρ = 0.4638, P<0.0001; and G5, creatinine clearance ρ = 0.5414, P<0.0001, combined CKD-EPI ρ = 0.5288, P<0.0001. In the global assessment, proteinuria displayed the highest significant correlations with cystatin (ρ = 0.5433, P<0.0001) and cystatin-based equations (Hoek: ρ=-0.5309, P<0.0001). When GFR < 60 mL/min: in stage 3, proteinuria-cystatin (ρ = 0.4341, P<0.0001); proteinuria-Hoek (ρ = −0.4105, P<0.0001); in stage 4, proteinuria-cystatin (ρ = 0.4877, P<0.0001); proteinuria-Hoek (ρ = −0.4877, P = 0.0026). Conclusions. At every stage of GFR < 60 mL/min, cystatin-based equations displayed better correlations with Tc-DTPA99m. Proteinuria and cystatin-based equations showed strong associations and high degrees of correlation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|