Impaired renal function in morbid obese patients with nonalcoholic fatty liver disease
| Autor: | Sara Gonçalves, Adília Costa, F. Carepa, Mariana V. Machado, Helena Cortez-Pinto, J. Coutinho |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Adipokine Renal function Comorbidity Kidney Function Tests Gastroenterology Body Mass Index Liver disease Liver Function Tests Non-alcoholic Fatty Liver Disease Risk Factors Internal medicine Nonalcoholic fatty liver disease Humans Medicine Prospective Studies Metabolic Syndrome Portugal Hepatology medicine.diagnostic_test Adiponectin business.industry Middle Aged medicine.disease digestive system diseases Obesity Morbid Fatty Liver Cross-Sectional Studies Endocrinology Kidney Failure Chronic Female Metabolic syndrome business Liver function tests Biomarkers Glomerular Filtration Rate Kidney disease |
| Zdroj: | Liver International. 32:241-248 |
| ISSN: | 1478-3223 |
| Popis: | Introduction and aims: Obesity is a common risk factor for nonalcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD). NAFLD and CKD have been associated in many epidemiological studies. We hypothesize that more severe liver disease, namely nonalcoholic steatohepatitis (NASH), is related with further renal impairment. We aimed to evaluate if changes in renal function were present in morbid obese patients with NAFLD. Methods Prospective and consecutive recruitment of morbid obese patients with biopsy proven NAFLD obtained during bariatric surgery. Renal function was evaluated with CKD-Epidemiology Collaboration estimated glomerular filtration rate (eGFR). Plasmatic adiponectin, leptin and active ghrelin concentrations were determined. Results One hundred and forty-eight patients were included of whom 25% had NASH and 75% simple steatosis. NASH patients were older, with higher body mass index and had more frequently metabolic syndrome and lower eGFR (97 ± 22 vs 106 ± 16 ml/min/1.732, P = 0.035). NASH conferred an odds ratio (OR) 3.0 (1.3–7.0) for eGFR |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text