Outbreak of Methicillin-Resistant Staphylococcus aureus with Reduced Susceptibility to Glycopeptides in a Parisian Hospital
| Autor: | Jean-Luc Mainardi, Annie Buu-Hoï, Guillaume Kac, Isabelle Podglajen, François Guérin, Sabine Vaupré, Nathalie Colardelle, Laurent Gutmann |
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| Rok vydání: | 2000 |
| Předmět: |
Male
Microbiology (medical) Paris Staphylococcus aureus Meticillin Epidemiology Fusidic acid Microbial Sensitivity Tests Biology medicine.disease_cause Disease Outbreaks Microbiology chemistry.chemical_compound Hospitals Urban medicine Humans Teicoplanin Glycopeptides Drug Resistance Microbial Staphylococcal Infections biochemical phenomena metabolism and nutrition Methicillin-resistant Staphylococcus aureus Virology Glycopeptide Anti-Bacterial Agents Electrophoresis Gel Pulsed-Field chemistry Brain heart infusion Vancomycin Female Methicillin Resistance medicine.drug |
| Zdroj: | Journal of Clinical Microbiology. 38:2985-2988 |
| ISSN: | 1098-660X 0095-1137 |
| DOI: | 10.1128/jcm.38.8.2985-2988.2000 |
| Popis: | Epidemiological relationships were investigated between 40 methicillin-resistant Staphylococcus aureus (MRSA) strains with decreased glycopeptide susceptibility isolated from November 1998 to March 1999 from 39 patients (17 infected and 22 colonized patients) in nine wards of the Broussais Hospital, Paris, France. Reduced glycopeptide susceptibility was readily detected on brain heart infusion (BHI) agar containing 6 μg of teicoplanin per ml and on gradient plates, but not by the standard disk diffusion method. The MICs of vancomycin and teicoplanin, determined on BHI agar, were 4 and 8 to 32 μg/ml, respectively (standard antibiotic dilution), and 4 to 8 and 8 to 32 μg/ml, respectively (E-test). All strains were resistant to macrolides, aminoglycosides, tetracycline, rifampin, sulfonamides, and pefloxacin, showed reduced susceptibility to fusidic acid and fosfomycin, and were susceptible to trimethoprim and chloramphenicol. Pulsed-field gel electrophoresis and lysotyping revealed that a multidrug-resistant MRSA clone with decreased susceptibility to glycopeptides has been discretely endemic since at least 1996 in our institution, where it was responsible for an outbreak in November and December 1998. |
| Databáze: | OpenAIRE |
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