| Autor: |
Mao-Mao Zhang, Bao-Le Qu, Bin Shi, Wen-Jing Xiao, Liang-Qiu Lu |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Chemical Society reviews. 51(10) |
| ISSN: |
1460-4744 |
| Popis: |
Medium-sized heterocycles are widespread among a spectrum of structurally intriguing and biologically significant natural products and synthetic pharmaceuticals. Metal-catalyzed high-order dipolar annulations resembling reactions of metal-containing reactive dipoles with dipolarophiles constitute a highly efficient and flexible strategy for constructing medium-sized heterocycles. Mechanistically, these annulation reactions usually proceeding through stepwise pathways are different from the classic high-order pericyclic reactions that follow the Woodward-Hoffman rules. More significantly, asymmetric high-order dipolar annulations using chiral organometallic catalysts have been proven successful for constructing chiral medium-sized heterocycles with high enantio- and diastereoselectivity. This review highlights the impressive advances in this area and is focused on the reactivity, scope, mechanisms and applications of high-order dipolar annulation reactions. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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