Monocyte Function Is Normal in Quiescent Psoriasis
| Autor: | J.P.M. Geerdink, M.R. Franzen, J.M. Gommans, Mieke Bergers, P.E.J. van Erp, P.D. Mier, P.H.M. de Mulder, Helga van Rennes |
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| Rok vydání: | 1984 |
| Předmět: |
Adult
Male medicine.medical_specialty Epinephrine Stimulation Dermatology Carbohydrate metabolism Biology Biochemistry Monocytes Internal medicine Psoriasis Cyclic AMP medicine Humans Alprostadil Molecular Biology Cells Cultured chemistry.chemical_classification Prostaglandins E Monocyte Cell Biology Middle Aged medicine.disease In vitro Glucose Endocrinology Enzyme medicine.anatomical_structure chemistry Luminescent Measurements Immunology Female Lysosomes Cell Division Function (biology) Hormone |
| Zdroj: | Journal of Investigative Dermatology. 82:122-125 |
| ISSN: | 0022-202X |
| DOI: | 10.1111/1523-1747.ep12259661 |
| Popis: | We report an investigation of peripheral blood monocytes from untreated patients with mild, quiescent psoriasis. Possible metabolic changes were monitored by the determination of 3 enzymes representing different pathways of glucose metabolism and 2 lysosomal enzymes. Signal processing was evaluated by the measurement of cyclic AMP levels before and after hormonal stimulation. Luminol-amplified chemiluminescence provided an objective approach to assessing phagocytic capacity. Finally, the pattern of maturation of normal and psoriatic monocytes has been compared during culture in vitro. Our results were uniformly and wholly negative; we conclude that the concept of an “intrinsic” abnormality of the psoriatic monocyte may be excluded. Possible reasons for discrepancies in the literature are discussed. |
| Databáze: | OpenAIRE |
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