Risk factors for early postoperative cognitive dysfunction after colorectal surgery
Autor: | Wei-Qing Jiang, Yun-Luo Lv, Chen Zhang, Hong-Yu Wang, Liu Han, Yuan Zhang, Yu-jie Gao, Yanna Si, Hongguang Bao |
---|---|
Rok vydání: | 2017 |
Předmět: |
Male
medicine.medical_specialty Colorectal cancer Anesthesia General Neuropsychological Tests law.invention lcsh:RD78.3-87.3 03 medical and health sciences 0302 clinical medicine Postoperative Cognitive Complications 030202 anesthesiology law Risk Factors Colorectal surgery Diabetes mellitus Internal medicine Anesthesiology medicine Diabetes Mellitus Humans SIRS Prospective Studies Postoperative cognitive dysfunction Aged business.industry Diabetes 030208 emergency & critical care medicine Fasting medicine.disease Intensive care unit Comorbidity Systemic Inflammatory Response Syndrome Cardiac surgery Anesthesiology and Pain Medicine lcsh:Anesthesiology Female business Colorectal Neoplasms Research Article |
Zdroj: | BMC Anesthesiology BMC Anesthesiology, Vol 19, Iss 1, Pp 1-6 (2019) |
ISSN: | 1471-2253 |
Popis: | Background It has been reported that postoperative cognitive dysfunction (POCD) is correlated with the degeneration of the central nervous system, oxidative stress, inflammation, and endocrine and immune dysfunction. Increased age, predisposed comorbidity, long surgery time, and prolonged stay in the intensive care unit have been reported to be risk factors for developing POCD for cardiac surgery. In the present study, the risk factors of early POCD after colorectal surgery were investigated. Methods Eighty patients, who provided informed consents for their participation in this study, were enrolled and received colorectal surgery under general anesthesia. Neuropsychological tests were performed preoperatively and on postoperative day seven. The risk factors for POCD were analyzed using a multivariate logistic regression model. Results Nineteen patients were diagnosed with POCD (24.7%). Diabetes history (OR = 8.391 [2.208–31.882], P = 0.012), fasting over 3 days after surgery (OR = 5.236 [1.998–13.721], P = 0.001) and an SIRS score of > 3 on the second day after surgery (OR = 6.995 [1.948–25.111], P = 0.003) were risk factors for early POCD in colorectal cancer patients. Conclusion The risk factors for early POCD after colorectal surgery included diabetes history, fasting over 3 days, and an SIRS score of > 3 on the second day. |
Databáze: | OpenAIRE |
Externí odkaz: |
načítá se...