Evaluation of the safety and efficacy of corifollitropin alfa combined with GnRH agonist triggering in oocyte donation cycles. A prospective longitudinal study
| Autor: | Hakan Yarali, Evangelos G. Papanikolaou, Andriana Virgiliou, Petroula Tatsi, Robert Najdecki, Apostolos Athanasiadis, Kallirhoe Kalinderi, Evi Timotheou, Georgios Michos, Ioannis Tsakiridis |
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| Rok vydání: | 2020 |
| Předmět: |
Agonist
Adult endocrine system Pregnancy Rate medicine.drug_class medicine.medical_treatment Ovarian hyperstimulation syndrome Alpha (ethology) Luteal phase Andrology Gonadotropin-Releasing Hormone Young Adult Ovulation Induction Pregnancy medicine Humans Longitudinal Studies Prospective Studies donor GnRH agonist triggering In vitro fertilisation Oocyte Donation business.industry Antagonist Fertility Agents Female corifollitropin alfa medicine.disease Oocyte medicine.anatomical_structure IVF Oocytes Ovulation induction Female Follicle Stimulating Hormone Human Original Article business |
| Zdroj: | JBRA Assisted Reproduction |
| ISSN: | 1518-0557 |
| Popis: | Objective: In order to help make the dream of parenthood come true for oocyte acceptors, it is essential that the procedure is not dangerous or unpleasant for oocyte donors. The aim of this study was to identify differences in safety, efficacy and patient acceptability between a traditional stimulation antagonist protocol with recombinant-FSH (rFSH) with hCG-triggering, compared with an innovative antagonist protocol with corifollitropin alfa (Elonva®) plus GnRH agonist triggering in oocyte donors. Methods: A prospective longitudinal study was conducted at an in vitro fertilization center in Greece. The same eighty donors underwent two consecutive antagonist stimulation schemes. Primary outcomes were patient satisfaction (scored by a questionnaire) and delivery rate per donor. Secondary outcomes were mean number of cumulus-oocyte-complexes, metaphase II (MII) oocytes and ovarian hyperstimulation syndrome (OHSS) rate. Results: Donors reported better adherence and less discomfort with the corifollitropin alpha + GnRH agonist-triggering protocol (p |
| Databáze: | OpenAIRE |
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