Complex Rearrangement of the Entire Retinal Posterior Pole in Patients with Relapsing Remitting Multiple Sclerosis
| Autor: | Carolina Gabri Nicoletti, Francesco Aiello, Carlo Nucci, Girolama Alessandra Marfia, Maria Albanese, Giorgia Mataluni, Matteo Di Marino, Alessio Martucci, Diego Centonze, Massimo Cesareo, Emiliano Di Carlo, Roberto Sorge, Nicola Biagio Mercuri, Doriana Landi, Giovanni Di Mauro, Raffaele Mancino |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
retina Posterior pole Nerve fiber layer Optic disk Settore MED/26 multiple sclerosis Article chemistry.chemical_compound Ophthalmology medicine Optic neuritis Ganglion cell layer Retina Retinal pigment epithelium business.industry Retinal optic nerve (ON) General Medicine medicine.disease posterior pole analysis medicine.anatomical_structure chemistry OCT Medicine sense organs business |
| Zdroj: | Journal of Clinical Medicine, Vol 10, Iss 4693, p 4693 (2021) Journal of Clinical Medicine Volume 10 Issue 20 |
| ISSN: | 2077-0383 |
| Popis: | There are consolidated data about multiple sclerosis (MS)–dependent retinal neurodegeneration occurring in the optic disk and the macula, although it is unclear whether other retinal regions are affected. Our objective is to evaluate, for the first time, the involvement of the entire retinal posterior pole in patients diagnosed with relapsing remitting multiple sclerosis (RRMS) unaffected by optic neuritis using Spectral Domain–Optical Coherence Tomography (SD–OCT). The study protocol was approved by Tor Vergata Hospital Institutional Ethics Committee (Approval number 107/16), and conforms to the tenets of the Declaration of Helsinki. After a comprehensive neurological and ophthalmological examination, 53 untreated RRMS patients (aged 37.4 ± 10) and 53 matched controls (aged 36.11 ± 12.94) were enrolled. In addition, each patient underwent an examination of the posterior pole using the SD-OCT built-in Spectralis posterior pole scanning protocol. After segmentation, the mean thickness, as well as the thickness of the 64 single regions of interest, were calculated for each retinal layer. No statistically significant difference in terms of average retinal thickness was found between the groups. However, MS patients showed both a significantly thinner ganglion cell layer (p < 0.001), and, although not statistically significant, a thinner inner nuclear layer (p = 0.072) and retinal nerve fiber layer (p = 0.074). In contrast, the retinal pigment epithelium (p = 0.014) and photoreceptor layers p < 0.001) resulted significantly thicker in these patients. Interestingly, the analysis of the region of interest showed that neurodegeneration was non-homogeneously distributed across each layer. This is the first report that suggests a complex rearrangement that affects, layer by layer, the entire retinal posterior pole of RRMS retinas in response to the underlying neurotoxic insult. |
| Databáze: | OpenAIRE |
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