Aggression subtypes relate to distinct resting state functional connectivity in children and adolescents with disruptive behavior
| Autor: | Lukasz Smigielski, Christoph Hofstetter, Melanie C Saam, Barbara Franke, Sarah Baumeister, Paramala Santosh, Jilly Naaijen, Maria J Penzol, Julia E Werhahn, Marcel P. Zwiers, Celso Arango, Andrea Dietrich, Leandra M Mulder, David J. Lythgoe, Alexander Roth, Pascal M Aggensteiner, Jeffrey C. Glennon, David Willinger, Mathilde Mastroianni, Tobias Banaschewski, Susanna Mohl, Renee Kleine Deters, Mireia Rosa, Núria Bargalló, Ilyas Sagar-Ouriaghli, Daniel Brandeis, Josefina Castro-Fornieles, Pieter J. Hoekstra, Ulrike M E Schulze, Susanne Walitza, Arjun Sethi, Philipp Stämpfli, Jan K. Buitelaar, Nathalie E. Holz, Michael C. Craig |
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| Přispěvatelé: | University of Zurich, Werhahn, Julia E, Brandeis, Daniel, Clinical Cognitive Neuropsychiatry Research Program (CCNP) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Aggressiveness in adolescence Precuneus NEUROBIOLOGY Poison control INVENTORY Pediatrics Functional connectivity 2738 Psychiatry and Mental Health 0302 clinical medicine 130 000 Cognitive Neurology & Memory PSYCHOPATHIC TRAITS Developmental and Educational Psychology 10064 Neuroscience Center Zurich Child Default mode network 0303 health sciences Connective tissues diseases CALLOUS-UNEMOTIONAL TRAITS 220 Statistical Imaging Neuroscience Original Contribution General Medicine 10058 Department of Child and Adolescent Psychiatry Amygdala Magnetic Resonance Imaging Perinatology Reactive aggression Aggression and Child Health Psychiatry and Mental health medicine.anatomical_structure Attention Deficit and Disruptive Behavior Disorders Conduct disorder Female Malalties del teixit connectiu medicine.symptom Psychology Clinical psychology Proactive aggression Adolescent 610 Medicine & health 150 000 MR Techniques in Brain Function OFFENDERS 03 medical and health sciences medicine Humans Agressivitat en els adolescents 2735 Pediatrics Perinatology and Child Health 030304 developmental biology Problem Behavior 3204 Developmental and Educational Psychology Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7] Resting state fMRI medicine.disease Posterior cingulate DEFAULT MODE NETWORK CONDUCT DISORDER 10054 Clinic for Psychiatry Psychotherapy and Psychosomatics Pediatrics Perinatology and Child Health Insula 030217 neurology & neurosurgery |
| Zdroj: | European Child & Adolescent Psychiatry, 30, 8, pp. 1237-1249 Dipòsit Digital de la UB Universidad de Barcelona European Child & Adolescent Psychiatry, 30, 1237-1249. SPRINGER European Child & Adolescent Psychiatry, 30, 1237-1249 European Child & Adolescent Psychiatry |
| ISSN: | 1018-8827 |
| Popis: | There is increasing evidence for altered brain resting state functional connectivity in adolescents with disruptive behavior. While a considerable body of behavioral research points to differences between reactive and proactive aggression, it remains unknown whether these two subtypes have dissociable effects on connectivity. Additionally, callous-unemotional traits are important specifiers in subtyping aggressive behavior along the affective dimension. Accordingly, we examined associations between two aggression subtypes along with callous-unemotional traits using a seed-to-voxel approach. Six functionally relevant seeds were selected to probe the salience and the default mode network, based on their presumed role in aggression. The resting state sequence was acquired from 207 children and adolescents of both sexes [mean age (standard deviation) = 13.30 (2.60); range = 8.02–18.35] as part of a Europe-based multi-center study. One hundred eighteen individuals exhibiting disruptive behavior (conduct disorder/oppositional defiant disorder) with varying comorbid attention-deficit/hyperactivity disorder (ADHD) symptoms were studied, together with 89 healthy controls. Proactive aggression was associated with increased left amygdala–precuneus coupling, while reactive aggression related to hyper-connectivities of the posterior cingulate cortex (PCC) to the parahippocampus, the left amygdala to the precuneus and to hypo-connectivity between the right anterior insula and the nucleus caudate. Callous-unemotional traits were linked to distinct hyper-connectivities to frontal, parietal, and cingulate areas. Additionally, compared to controls, cases demonstrated reduced connectivity of the PCC and left anterior insula to left frontal areas, the latter only when controlling for ADHD scores. Taken together, this study revealed aggression-subtype-specific patterns involving areas associated with emotion, empathy, morality, and cognitive control. Electronic supplementary material The online version of this article (10.1007/s00787-020-01601-9) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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