Immunotherapy and radiotherapy in melanoma: a multidisciplinary comprehensive review
Autor: | Ketty Peris, C. Casà, Andrea D'Aviero, Luca Tagliaferri, Giampaolo Tortora, Stefania Manfrida, Silvia Chiesa, Giovanni Schinzari, Bruno Fionda, Monica Mangoni, Monica Maria Pagliara, Valentina Lancellotta, C. Mazzarella, Vincenzo Valentini, Alessio G. Morganti, Fabio Marazzi, Alessandro Di Stefani, Giuseppe Colloca, Maria Antonietta Blasi |
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Přispěvatelé: | Tagliaferri L., Lancellotta V., Fionda B., Mangoni M., Casa C., Di Stefani A., Pagliara M.M., D'Aviero A., Schinzari G., Chiesa S., Mazzarella C., Manfrida S., Colloca G.F., Marazzi F., Morganti A.G., Blasi M.A., Peris K., Tortora G., Valentini V. |
Rok vydání: | 2021 |
Předmět: |
Oncology
medicine.medical_specialty medicine.medical_treatment 030231 tropical medicine Immunology Ocular Melanoma Disease radiation therapy 03 medical and health sciences 0302 clinical medicine Multidisciplinary approach Internal medicine Immunogenic tumor medicine Tumor Microenvironment Immunology and Allergy Humans Immunologic Factors 030212 general & internal medicine Prospective Studies Melanoma Aged Pharmacology Tumor microenvironment Radiotherapy business.industry Immunotherapy medicine.disease Combined Modality Therapy Radiation therapy business Settore MED/35 - MALATTIE CUTANEE E VENEREE |
Zdroj: | Human vaccinesimmunotherapeutics. 18(3) |
ISSN: | 2164-554X |
Popis: | Melanoma is an extremely aggressive tumor and is considered to be an extremely immunogenic tumor because compared to other cancers it usually presents a well-expressed lymphoid infiltration. The aim of this paper is to perform a multidisciplinary comprehensive review of the evidence available about the combination of radiotherapy and immunotherapy for melanoma. Radiation, in fact, can increase tumor antigens visibility and promote priming of T cells but can also exert immunosuppressive action on tumor microenvironment. Combining radiotherapy with immunotherapy provides an opportunity to increase immunostimulatory potential of radiation. We therefore provide the latest clinical evidence about radiobiological rationale, radiotherapy techniques, timing, and role both in advanced and systemic disease (with a special focus on ocular melanoma and brain, liver, and bone metastases) with a particular attention also in geriatric patients. The combination of immunotherapy and radiotherapy seems to be a safe therapeutic option, supported by a clear biological rationale, even though the available data confirm that radiotherapy is employed more for metastatic than for non-metastatic disease. Such a combination shows promising results in terms of survival outcomes; however, further studies, hopefully prospective, are needed to confirm such evidence. |
Databáze: | OpenAIRE |
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