Protective roles for myeloid cells in neuroinflammation
| Autor: | Anouk Benmamar-Badel, Marlene Thorsen Mørch, Gill Webster, Dina S. Arengoth, Trevor Owens, Magdalena Dubik, Reza Khorooshi, Agnieszka Wlodarczyk, Joanna Marczynska, Nasrin Asgari |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Central Nervous System Encephalomyelitis Autoimmune Experimental Multiple Sclerosis Immunology microglia Inflammation multiple sclerosis medicine.disease_cause Autoimmunity 03 medical and health sciences 0302 clinical medicine neutrophils Medicine Animals Humans Myeloid Cells Neuroinflammation Innate immune system Microglia business.industry Regeneration (biology) Multiple sclerosis Macrophages autoimmunity Experimental autoimmune encephalomyelitis General Medicine Dendritic Cells suppression medicine.disease cytokines macrophages 030104 developmental biology medicine.anatomical_structure inflammation innate receptors medicine.symptom monocytes business 030215 immunology Granulocytes |
| Zdroj: | Owens, T, Benmamar-Badel, A, Wlodarczyk, A, Marczynska, J, Mørch, M T, Dubik, M, Arengoth, D S, Asgari, N, Webster, G & Khorooshi, R 2020, ' Protective roles for myeloid cells in neuroinflammation ', Scandinavian Journal of Immunology, vol. 92, no. 5, e12963 . https://doi.org/10.1111/sji.12963 |
| ISSN: | 1365-3083 |
| Popis: | Myeloid cells represent the major cellular component of innate immune responses. Myeloid cells include monocytes and macrophages, granulocytes (neutrophils, basophils and eosinophils) and dendritic cells (DC). The role of myeloid cells has been broadly described both in physiological and in pathological conditions. All tissues or organs are equipped with resident myeloid cells, such as parenchymal microglia in the brain, which contribute to maintaining homeostasis. Moreover, in case of infection or tissue damage, other myeloid cells such as monocytes or granulocytes (especially neutrophils) can be recruited from the circulation, at first to promote inflammation and later to participate in repair and regeneration. This review aims to address the regulatory roles of myeloid cells in inflammatory diseases of the central nervous system (CNS), with a particular focus on recent work showing induction of suppressive function via stimulation of innate signalling in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). |
| Databáze: | OpenAIRE |
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