Analysis of cellular phenotypes that mediate genetic resistance to tuberculosis using a radiation bone marrow chimera approach
| Autor: | Elvira I. Rubakova, Evgeny B. Eruslanov, Alexander S. Apt, Konstantin B. Majorov, Tatiana Kondratieva |
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| Rok vydání: | 2005 |
| Předmět: |
Adoptive cell transfer
Bone Tuberculosis Mice Inbred A Immunology Bone Marrow Cells Biology Microbiology Immunophenotyping Mycobacterium tuberculosis Chimera (genetics) Mice medicine Animals Genetic Predisposition to Disease Lung Tuberculosis Pulmonary Bone Marrow Transplantation Host Response and Inflammation biology.organism_classification Molecular biology Adoptive Transfer Infectious Diseases medicine.anatomical_structure Phenotype Radiation Chimera Parasitology Female Bone marrow CD8 |
| Zdroj: | Infection and immunity. 73(9) |
| ISSN: | 0019-9567 |
| Popis: | Adoptive transfer of bone marrow cells from tuberculosis-resistant (I/St × A/Sn)F1donor mice into lethally irradiated susceptible I/St recipients changed their phenotype following infection with virulentMycobacterium tuberculosis. Compared to I/St→I/St control animals, F1→I/St chimeras demonstrated (i) prolonged survival time, (ii) increased antimycobacterial function of lung macrophages, (iii) elevated gamma interferon production by lung cells, and (iv) decreased infiltration of the lungs with CD4+and CD8+T cells and Ly-6G+neutrophils. |
| Databáze: | OpenAIRE |
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