UDP-glucuronosyltransferase 1A7 polymorphisms are associated with liver cirrhosis
| Autor: | May-Jen Huang, Ching-Shan Huang, Chuan-Mo Lee, Kung-Sheng Tang, Hsiu-Chen Teng |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Liver Cirrhosis medicine.medical_specialty Cirrhosis Hepatitis C virus DNA Mutational Analysis Biophysics Taiwan Logistic regression medicine.disease_cause Biochemistry Gastroenterology Polymorphism Single Nucleotide Risk Assessment Pathogenesis Apolipoproteins E Risk Factors Internal medicine Genotype Medicine Humans Genetic Predisposition to Disease Genetic Testing Glucuronosyltransferase Molecular Biology Aged Hepatitis B virus Aged 80 and over business.industry Incidence Cell Biology Odds ratio Middle Aged medicine.disease Virology digestive system diseases Hepatocellular carcinoma Female business |
| Zdroj: | Biochemical and biophysical research communications. 366(3) |
| ISSN: | 1090-2104 |
| Popis: | Variations in the UDP-glucuronosyltransferase (UGT) 1A7 gene have been found to be related to the development of hepatocellular carcinoma (HCC). Since the pathogenesis of liver cirrhosis is not dissimilar to that of HCC, we hypothesized that UGT1A7 genetic polymorphisms may be associated with liver cirrhosis. PCR-restriction fragment length polymorphism was utilized to determine UGT for 1A7 genotypes for the 159 patients with liver cirrhosis and 263 gender/age matched controls. Simple logistic regression analysis revealed that significant risk factors for liver cirrhosis were (1) hepatitis B virus (HBV) infection, (2) hepatitis C virus (HCV) infection, (3) HBV infection plus HCV infection and (4) low-activity UGT1A7 genotypes. The results of further multivariate logistic regression confirmed these associations. Interaction of low-activity UGT1A7 genotypes and HBV (or HCV) infection produced an additive effect upon the risk for the development of liver cirrhosis [observed odds ratio (OR) (54.59) greater than the expected OR (18.05)]. UGT1A7 low/low genotype was also related to advanced liver cirrhosis (Child-Pugh classes C and/or B) (OR=7.50, P=0.009). This study demonstrates the novel findings that carriage of low-activity UGT1A7 genotypes represents a risk factor for the development and functional severity of liver cirrhosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect