Variant clinical courses in children with immune thrombocytopenic purpura: Sixteen year experience of a single medical center
| Autor: | Isin Yaprak, İkbal Durak, Berna Atabay, Haldun Öniz, Meral Türker, Esra Arun Ozer |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
lcsh:Internal medicine
Pediatrics medicine.medical_specialty Common disease clinical course Age at diagnosis Newly diagnosed recurrent Immune system children immune system diseases hemic and lymphatic diseases medicine In patient Acquired thrombocytopenia lcsh:RC31-1245 Response rate (survey) lcsh:RC633-647.5 business.industry lcsh:Diseases of the blood and blood-forming organs Hematology medicine.disease Thrombocytopenic purpura chronic Immune thrombocytopenic purpura outcome business |
| Zdroj: | Turkish Journal of Hematology, Vol 27, Iss 03, Pp 147-155 (2010) |
| ISSN: | 1308-5263 1300-7777 |
| DOI: | 10.5152/tjh.2010.21 |
| Popis: | Immune thrombocytopenic purpura (ITP) is the most common cause of acquired thrombocytopenia in children. The objective of this study was to evaluate the presenting features, variation in the clinical courses, initial response rate to therapy, and long-term outcome in patients with ITP.Three hundred and fifty out of 491 newly diagnosed patients with ITP between the initial diagnosis ages of 6 months to 16 years were included in this retrospective, descriptive study. Patients with acute vs chronic ITP, acute vs recurrent ITP and chronic vs recurrent ITP were compared in terms of age at diagnosis, gender, initial platelet count, response rate to initial therapy, long-term outcome, and total duration of follow-up.The clinical courses of the patients were determined as acute, chronic and recurrent in 63.8%, 29.1%, and 7.1%, respectively. Platelet count20x109/L and initial diagnosis age10 years were found to increase the probability of chronic outcome by at least two-fold.It is concluded that ITP in childhood is a common disease with low morbidity and mortality. In addition to the acute and chronic form, a rare recurrent form, which accounts for about 4-7% of all ITP patients, should be considered.AMAÇ: İmmun trombositopenik purpura (ITP) çocukluk çağında en sık görülen edinsel trombositopeni nedenlerindendir. Bu çalışmada, ITP’li çocuklarda başvuru bulguları, klinik seyirlerindeki farklılıklar, tedaviye ilk yanıt ve uzun dönem prognozlarının değerlendirilmesi amaçlandı. YÖNTEMLER: Bu retrospektif, tanımlayıcı araştırmaya tanı yaşı 6 ay-16 yıl olan ITP’li 491 hastadan 350’si dahil edildi. Akut, kronik ve rekürren ITP’li olgular tanı yaşı, cinsiyet, başvurudaki trombosit sayısı, ilk tedavi yanıtı, prognoz ve izlem süreleri yönünden ikili gruplar halinde karşılaştırıldı.Hastaların %63.8’i akut, %29.1’i kronik ve %7.1’i rekürren ITP olarak tanımlandı. Trombosit sayısı20x109/L ve başvuru yaşının10 yaş olmanın kronik ITP olasılığını 2 kat arttırdığı görüldü. SONUÇ: Sonuç olarak ITP, çocukluk yaş grubunda mortalite ve morbiditesi düşük bir hastalıktır. Akut ve kronik seyirli ITP dışında, tüm ITP olgularının %4-7’sini oluşturan rekürren formların da olabileceği akılda tutulmalıdır. |
| Databáze: | OpenAIRE |
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