Epstein-Barr virus-associated large granular lymphocyte leukemia with cutaneous infiltration
| Autor: | Koji Hashimoto, Teiichi Yamamura, Kunihiko Yoshikawa, Hideki Tei, Hideo Asada, Natsuko Okada, Kazuhiro Kondo, Koichi Yamanishi |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Herpesvirus 4 Human Leukemia T-Cell Fluorescent Antibody Technique Dermatology medicine.disease_cause Virus Herpesviridae Antigen Leukemic Infiltration hemic and lymphatic diseases medicine Gammaherpesvirinae Humans Skin biology T lymphocyte Herpesviridae Infections medicine.disease biology.organism_classification Epstein–Barr virus Virology Leukemia Blotting Southern Tumor Virus Infections Immunology DNA Viral |
| Zdroj: | Europe PubMed Central |
| ISSN: | 0190-9622 |
| Popis: | A 36-year-old man had a high titer of antibody to Epstein-Barr virus (EBV) and recurrent necrotizing papules and nodules on his face and oral mucosa. The disease was diagnosed as CD3+4- 8+ large granular lymphocyte leukemia of T-cell origin. Southern blot analysis demonstrated that EBV DNA was present in CD8+ lymphocytes; EBV antigens were also observed in these lymphocytes. These findings demonstrated that EBV latently infected the leukemic cells and may have played a role in the pathogenesis of this disease. This is the first report of an association between EBV and large granular lymphocyte leukemia of T-cell origin. |
| Databáze: | OpenAIRE |
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