Myasthenic crisis with delayed recovery after plasmapheresis
| Autor: | Noritoshi Shibuya, Hirofumi Goto, Takayasu Fukudome, Hajime Izumoto, Satoshi Fujishita, Izumi Ohtsuru, Hidenori Matsuo |
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| Rok vydání: | 1999 |
| Předmět: |
Male
animal structures Time Factors medicine.medical_treatment Severity of Illness Index Recurrence Severity of illness Myasthenia Gravis medicine Humans Immunoadsorption Immunosorbent Techniques Aged biology business.industry General Medicine Plasmapheresis musculoskeletal system medicine.disease Myasthenia gravis Titer Treatment Outcome Concomitant Anesthesia Immunology Prednisolone biology.protein Female Antibody business tissues medicine.drug Follow-Up Studies |
| Zdroj: | Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis. 3(4) |
| ISSN: | 1091-6660 |
| Popis: | We report on 2 elderly patients with myasthenia gravis in whom recovery from crisis was prolonged despite intensive plasmapheresis (PP). In both patients, the anti-acetylcholine (anti-AChR) titer failed to fall sufficiently after completing PP. These patients might have had antibodies that produced a more pronounced effect on the degradation of AChR, or the synthesis of AChR might have been reduced by aging. The anti-AChR titer did not correlate with a reduction of IgG after PP in 1 patient. Successful treatment was achieved by keeping the anti-AChR titer at a low level via the concomitant use of prednisolone with PP. |
| Databáze: | OpenAIRE |
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