Synthesis, Characterization and Application of Thermoresponsive Polyhydroxyalkanoate-graft-Poly(N-isopropylacrylamide)
Autor: | Lin-Ping Wu, Guo-Qiang Chen, Hui Yao, Yiming Ma, Daixu Wei |
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Rok vydání: | 2016 |
Předmět: |
Polymers and Plastics
Polymers Acrylic Resins Molecular Conformation Bioengineering 02 engineering and technology 010402 general chemistry 01 natural sciences Oligomer Polymerization Biomaterials chemistry.chemical_compound Aminolysis Polymer chemistry Materials Testing Materials Chemistry Copolymer Chemistry Polyhydroxyalkanoates Temperature Water Chain transfer Raft 021001 nanoscience & nanotechnology 0104 chemical sciences Models Chemical Poly(N-isopropylacrylamide) Click chemistry Thermodynamics 0210 nano-technology |
Zdroj: | Biomacromolecules. 17(8) |
ISSN: | 1526-4602 |
Popis: | A thermoresponsive graft copolymer polyhydroxyalkanoate-g-poly(N-isopropylacrylamide) or short as PHA-g-PNIPAm, was successfully synthesized via a three-step reaction. First, PNIPAm oligomer with a trithiocarbonate-based chain transfer agent (CTA), short as PNIPAm-CTA, with designed polymerization degree was synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization. Subsequently, the PNIPAm-CTA was treated with n-butylamine for aminolysis in order to obtain a pendant thiol group at the end of the chain (PNIPAm-SH). Finally, the PNIPAm-SH was grafted onto unsaturated P(3HDD-co-3H10U), a random copolymer of 3-hydroxydodecanoate (3HDD) and 3-hydroxy-10-undecylenate (3H10U), via a thiol-ene click reaction. Enhanced hydrophilicity and thermoresponsive property of the resulted PHA-g-PNIPAm were confirmed by water contact angle studies. The biocompatibility of PHA-g-PNIPAm was comparable to poly-3-hydroxybutyrate (PHB). The graft copolymer PHA-g-PNIPAm based on biopolyester PHA could be a promising material for biomedical applications. |
Databáze: | OpenAIRE |
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