Association of human papillomavirus infection and vulvar intraepithelial neoplasia: a morphological and immunohistochemical study of 30 cases
| Autor: | Guillermo di Paola, Nidia Gómez Rueda-Leverone, Susana Vighi, Fernando Llamosas, Roberto Meiss |
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| Rok vydání: | 1987 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Uterine Cervical Neoplasms Stromal Invasion Lesion Immunoenzyme Techniques Neoplasms Multiple Primary Medicine Humans Papillomaviridae Antigens Viral Vulvar neoplasm biology Vulvar Neoplasms business.industry Histocytochemistry HPV infection Obstetrics and Gynecology Middle Aged biology.organism_classification medicine.disease Vulvar intraepithelial neoplasia female genital diseases and pregnancy complications Koilocyte Tumor Virus Infections Oncology Immunohistochemistry Female medicine.symptom business Precancerous Conditions |
| Zdroj: | Gynecologic oncology. 26(3) |
| ISSN: | 0090-8258 |
| Popis: | Thirty cases of vulvar intraepithelial neoplasia (VIN) were analyzed in order to determine the frequency of association with human papillomavirus (HPV) infection, and the relationship between this association and patient's age, extent of vulvar lesions, and coexistence with cervicovaginal neoplasia. The presence of condyloma or moderate to marked koilocytosis, now considered as morphological evidence of HPV infection, was observed in 66.6% of our cases. A search for HPV antigens, using the peroxidase-antiperoxidase (PAP) method, was performed in 13 selected cases, and positive staining was detected in 3 of them. The presence of HPV infection correlates with a mean age of 48.8 years, 50% of multicentricity of VIN and coexistence with cervical neoplasia in 30% of the cases, as opposed to a mean age of 55.5 years, 10% of multicentricity of VIN and absence of cervical neoplasia in patients without HPV infection. The demonstration of multiple foci of early stromal invasion in a 43-year-old woman, with multicentric VIN lesions associated with HPV infection, indicates that, even in the presence of such clinicopathological features, the risk of developing stromal invasion should be considered. Considerations are made in relation with the presence of HPV antigen in morphological normal epithelium adjacent to the lesion. Therapeutic implications were also investigated. |
| Databáze: | OpenAIRE |
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