The Urinary Metabolome of Healthy Newborns
| Autor: | Rahmatollah Rajabzadeh, Juan José Oropeza-Valdez, Ana Sofía Herrera-Van Oostdam, Mariana Salgado-Bustamante, Rupasri Mandal, Emilia Robles Arguelles, Joel Monárrez-Espino, Victoria Lima-Rogel, Jiamin Zheng, David S. Wishart, Yamilé López-Hernández, An Chi Guo, Jorge O. Blanco-Sandate, Claudia G. Castillo, Jesus Adrian-Lopez |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Endocrinology Diabetes and Metabolism Metabolite Urinary system Normal urine lcsh:QR1-502 Physiology inborn errors of metabolism Urine Biochemistry lcsh:Microbiology Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Metabolomics newborn tandem mass spectrometry Metabolome Medicine Human Metabolome Database Molecular Biology metabolites business.industry reference values 030104 developmental biology chemistry General health business 030217 neurology & neurosurgery |
| Zdroj: | Metabolites Volume 10 Issue 4 Metabolites, Vol 10, Iss 165, p 165 (2020) |
| ISSN: | 2218-1989 |
| DOI: | 10.3390/metabo10040165 |
| Popis: | The knowledge of normal metabolite values for neonates is key to establishing robust cut-off values to diagnose diseases, to predict the occurrence of new diseases, to monitor a neonate&rsquo s metabolism, or to assess their general health status. For full term-newborns, many reference biochemical values are available for blood, serum, plasma and cerebrospinal fluid. However, there is a surprising lack of information about normal urine concentration values for a large number of important metabolites in neonates. In the present work, we used targeted tandem mass spectrometry (MS/MS)-based metabolomic assays to identify and quantify 136 metabolites of biomedical interest in the urine from 48 healthy, full-term term neonates, collected in the first 24 h of life. In addition to this experimental study, we performed a literature review (covering the past eight years and over 500 papers) to update the references values in the Human Metabolome Database/Urine Metabolome Database (HMDB/UMDB). Notably, 86 of the experimentally measured urinary metabolites are being reported in neonates/infants for the first time and another 20 metabolites are being reported in human urine for the first time ever. Sex differences were found for 15 metabolites. The literature review allowed us to identify another 78 urinary metabolites with concentration data. As a result, reference concentration values and ranges for 378 neonatal urinary metabolites are now publicly accessible via the HMDB. |
| Databáze: | OpenAIRE |
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