Associations between urinary diphenyl phosphate and thyroid function
| Autor: | Michael D. McClean, Colleen M. Makey, Thomas F. Webster, Birgit Claus Henn, Elizabeth N. Pearce, Lewis E. Braverman, Emma V. Preston, Heather M. Stapleton |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Thyrotropin Urine Thyroid Function Tests 010501 environmental sciences 01 natural sciences Thyroid function tests Article Young Adult 03 medical and health sciences chemistry.chemical_compound Sex Factors Thyroid-stimulating hormone Internal medicine medicine Humans Child lcsh:Environmental sciences Aged Flame Retardants 0105 earth and related environmental sciences General Environmental Science lcsh:GE1-350 Air Pollutants Triiodothyronine medicine.diagnostic_test Chemistry Environmental Exposure Environmental exposure Middle Aged Organophosphates Confidence interval Thyroxine 030104 developmental biology Endocrinology DPHP Child Preschool Female Thyroid function Boston |
| Zdroj: | Environment International, Vol 101, Iss, Pp 158-164 (2017) |
| ISSN: | 0160-4120 |
| Popis: | Triphenyl phosphate (TPHP) is a commonly used organophosphate flame retardant and plasticizer with widespread human exposure. Data on health effects of TPHP are limited. Recent toxicological studies suggest TPHP may alter thyroid function. We used repeated measures to assess the temporal variability in urinary concentrations of the TPHP metabolite, diphenyl phosphate (DPHP), and to examine relationships between DPHP concentrations and thyroid hormones. We sampled 51 adults at months 1, 6, and 12 from 2010 to 2011. Urine samples were analyzed for DPHP. Serum samples were analyzed for free and total thyroxine (fT4, TT4), total triiodothyronine (TT3), and thyroid stimulating hormone (TSH). We assessed variability in DPHP using intraclass correlation coefficients (ICCs) and kappa statistics. We used linear mixed-effects models to examine associations between DPHP and thyroid hormones. DPHP was detected in 95% of urine samples. Mean DPHP concentrations were 43% higher in women than men. DPHP showed high within-subject variability (ICC range, 0.13–0.39; kappa range, 0.16–0.39). High versus low (≥2.65 vs. |
| Databáze: | OpenAIRE |
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