Levocabastine: pharmacological profile of a highly effective inhibitor of allergic reactions
| Autor: | Anton Megens, Frans Awouters, Carlos J. E. Niemegeers, T. Jansen, P. A. J. Janssen |
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| Rok vydání: | 1992 |
| Předmět: |
Ketotifen
Allergy Immunology Guinea Pigs Histamine H1 receptor Pharmacology Toxicology chemistry.chemical_compound Dogs Piperidines Oral administration medicine Hypersensitivity Animals p-Methoxy-N-methylphenethylamine Pharmacology (medical) Anaphylaxis Conjunctivitis Allergic business.industry Ascaris Passive Cutaneous Anaphylaxis medicine.disease Levocabastine Allergic conjunctivitis Rats chemistry Histamine H1 Antagonists business Histamine medicine.drug |
| Zdroj: | Agents and actions. 35(1-2) |
| ISSN: | 0065-4299 |
| Popis: | Levocabastine, selected from a series of cyclohexylpiperidine derivatives protects rats from compound 48/80-induced anaphylactic shock for at least 16 h at the oral dose of 0.0015 mg/kg. At the same dose histamine skin reactions and at slightly higher doses passive cutaneous anaphylactic reactions are inhibited. Blockade of passive cutaneous anaphylactic reactions is obtained with levocabastine, despite absence of peripheral serotonin antagonism and any other known non-specific action that may facilitate inhibition of passive anaphylaxis. In dogs allergic reactions are inhibited at oral doses 40 times lower than ketotifen. In guinea-pigs orally and topically administered levocabastine are remarkably effective against allergic conjunctivitis. |
| Databáze: | OpenAIRE |
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