Effect of smoking on activity of N-acetyl-beta-hexosaminidase in serum and urine of renal cancer patients
| Autor: | Krzysztof Zwierz, Małgorzata Knaś, Agnieszka Zaniewska, Barbara Darewicz, Anna Borzym-Lewszuk, Sławomir Dariusz Szajda, Małgorzata Borzym-Kluczyk, Iwona Radziejewska |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Clinical Biochemistry Oligosaccharides Urine Nitrophenols N acetyl β Risk Factors Internal medicine Biomarkers Tumor Medicine Humans Hexosaminidase chemistry.chemical_classification business.industry Catabolism Smoking Cancer General Medicine Oligosaccharide medicine.disease Kidney Neoplasms beta-N-Acetylhexosaminidases Enzyme Endocrinology chemistry business Hexosaminidase activity |
| Zdroj: | Clinical biochemistry. 42(15) |
| ISSN: | 1873-2933 |
| Popis: | Objectives To compare N-acetyl-β-hexosaminidase (HEX) activity in the serum and urine of smokers as well as non-smokers with renal cancer, and healthy people. Design and methods To assess hexosaminidase activity the level of p-nitrophenol released from p-nitrophenol derivatives was measured. Results The activity of enzyme was significantly higher in cancer group, with the highest activity in non-smokers. Conclusions Cigarette smoking can inhibit, by the influence on HEX activity, catabolism of oligosaccharide chains in cancer tissues. |
| Databáze: | OpenAIRE |
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