Increase in meningococcal disease associated with the emergence of a novel ST-11 variant of serogroup C Neisseria meningitidis in Victoria, Australia, 1999-2000
| Autor: | H. Y. Li, A. M. Zaia, Kath Taylor, Priscilla Robinson, David Tribe, Geoff Hogg, Julia M. Griffith |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
DNA Bacterial Male Adolescent Victoria Epidemiology Meningitis Meningococcal Neisseria meningitidis Meningococcal disease medicine.disease_cause DNA sequencing Microbiology medicine Humans Serologic Tests Allele Child DNA Primers biology Incidence (epidemiology) Age Factors Infant Newborn Outbreak Infant Sequence Analysis DNA biology.organism_classification medicine.disease Virology Housekeeping gene Epidemiologic Studies Infectious Diseases Phenotype Child Preschool Neisseriaceae Female Research Article |
| Zdroj: | Epidemiology and infection. 128(1) |
| ISSN: | 0950-2688 |
| Popis: | In the years 1999–2000, there was an increase in the incidence of meningococcal disease in Victoria, largely caused by Neisseria meningitidis serogroup C. This change was associated with a shift in age distribution of cases, with relatively more disease appearing in the 15–29 year age group, and with 40/58 serogroup C isolates in 2000 exhibiting a new macrorestriction pattern (pattern A). Thirty-four of 52 pattern A isolates tested displayed the novel phenotype C:2a:P1.4, and were consistently porA VR type P1.7-2,4 by DNA sequencing. Nine of 10 representative pattern A isolates analysed displayed a housekeeping gene allele profile (ST-11) that is characteristic of the electrophoretic type (ET)-15 variant that has caused outbreaks in Canada, the Czech Republic and Greece. Meningococci belonging to the ST-11 complex that were isolated in Victoria prior to 1999 did not display either restriction pattern A or PorA VR type P1.7-2,4. |
| Databáze: | OpenAIRE |
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