Synthesis of New Cationic Lipids from an Unsaturated Glycoside Scaffold

Autor:	Nathalie Mignet, Daniel Scherman, Marie Jose Egron, Nicolas Leforestier, Alain Quenot, Françoise Leclercq, Barbara Wetzer, Jean Herscovici
Rok vydání:	2001
Předmět:	chemistry.chemical_classification Scaffold Chemistry Organic Chemistry Acetal Molecular Conformation Cationic polymerization Glycoside DNA Lipids Biochemistry Combinatorial chemistry chemistry.chemical_compound Cations Amide Amphiphile Glycosides Physical and Theoretical Chemistry
Zdroj:	Organic Letters. 3:1893-1896
ISSN:	1523-7052 1523-7060
DOI:	10.1021/ol0159423
Popis:	[see structure]. We report the synthesis of new cationic lipids. These amphiphiles present a hydrophobic domain connected to a guanidinium entity by an unsaturated glycoside scaffold. The synthetic strategy using amide or acetal linkage led to various mono- and bicatenar derivatives. Investigation of their physicochemical properties indicated that these new compounds compact DNA.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82259636fd2f8bcdfc9755681bc5d251 https://doi.org/10.1021/ol0159423 Zobrazit plný text záznamu