Fatty liver is an independent risk factor for gallbladder polyps
| Autor: | Soon Ho Yoon, Kook Lae Lee, Doo Hee Lee, Sang Joon Park, Byeong Gwan Kim, Sohee Oh, Su Hwan Kim, Jinwoo Kang, Ji Bong Jeong, Dong Won Ahn, Ji Won Kim |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Sarcopenia medicine.medical_specialty Body fat distribution Gallbladder Diseases Visceral obesity Gastroenterology Body Mass Index 03 medical and health sciences 0302 clinical medicine Gallbladder polyp Internal medicine medicine Humans Risk factor Retrospective Studies medicine.diagnostic_test business.industry Gallbladder Fatty liver General Medicine Odds ratio Case Control Study Middle Aged medicine.disease Obesity Fatty Liver medicine.anatomical_structure Risk factors 030220 oncology & carcinogenesis Abdominal ultrasonography Female 030211 gastroenterology & hepatology business |
| Zdroj: | World Journal of Gastroenterology |
| ISSN: | 1007-9327 |
| Popis: | BACKGROUND Gallbladder polyps (GBPs) are known to be associated with obesity and metabolic diseases. However, to date, the relationship between GBPs and abnormal body fat distribution, such as fatty liver, visceral obesity, or sarcopenia, has not yet been established. AIM To evaluate whether GBPs are associated with fatty liver, visceral obesity, or sarcopenia. METHODS We retrospectively reviewed the medical records of subjects who underwent various laboratory tests, body composition measurement with a non-invasive body composition analyzer, and abdominal ultrasonography during health checkups. A total of 1405 subjects with GBPs were compared with 2810 age- and sex-matched controls. RESULTS The mean age of the subjects was 46.8 ± 11.7 years, and 63.8% were male. According to multiple logistic regression analysis, the presence of fatty liver [odds ratio (OR) 1.413; 95% confidence interval (CI) 1.218-1.638; P < 0.001] was an independent risk factor for GBP, together with low levels of alanine aminotransferase (OR 0.993; 95%CI 0.989-0.996; P < 0.001). Additionally, fatty liver showed both independent (OR 1.629; 95%CI, 1.335-1.988; P < 0.001) and dose-dependent (moderate to severe fatty liver; OR 2.137; 95%CI, 1.662-2.749; P < 0.001) relationship with large GBPs (≥ 5 mm). The presence of sarcopenia and high visceral fat area were not significantly associated with GBPs. CONCLUSION Fatty liver was found to be closely associated with GBPs irrespective of sarcopenia and visceral obesity. |
| Databáze: | OpenAIRE |
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