Development of a core outcome set for use in community-based bipolar trials—A qualitative study and modified Delphi

Autor:	John Gibson, Ruth Sayers, Maximillian Birchwood, Bliss Gibbons, Gemma M J Taylor, Humera Plappert, Ameeta Retzer, Peter Huxley, Thomas Keeley, Vanessa Pinfold, Jonathan Mathers, Melanie Calvert
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Research design medicine.medical_specialty Bipolar Disorder Delphi Technique Endpoint Determination Science Delphi method law.invention 03 medical and health sciences 0302 clinical medicine Quality of life (healthcare) Randomized controlled trial law Health care medicine Humans 030212 general & internal medicine Qualitative Research Clinical Trials as Topic Multidisciplinary business.industry 030503 health policy & services Focus Groups Focus group Outcome and Process Assessment Health Care Treatment Outcome Reporting bias Research Design Family medicine Medicine 0305 other medical science business Qualitative research RC Research Article
Zdroj:	PLoS ONE PLoS ONE, Vol 15, Iss 10, p e0240518 (2020) Retzer, A, Sayers, R, Pinfold, V, Gibson, J, Keeley, T, Taylor, G, Plappert, H, Gibbons, B, Huxley, P, Mathers, J, Birchwood, M & Calvert, M 2020, ' Development of a Core Outcome Set for use in community-based bipolar trials-A qualitative study and modified Delphi ', PLoS ONE .
ISSN:	1932-6203
Popis:	Background:\ud A core outcome set (COS) is a standardised collection of outcomes to be collected and reported in all trials within a research area. A COS can reduce reporting bias and facilitate evidence synthesis. This is currently unavailable for use in community-based bipolar trials. This research aimed to develop such a COS, with input from a full range of stakeholders.\ud \ud Methods:\ud A co-production approach was used throughout. A longlist of outcomes was derived from focus groups with people with a bipolar diagnosis and carers, interviews with healthcare professionals and a rapid review of outcomes listed in bipolar trials on the Cochrane database. An expert panel with personal and/or professional experience of bipolar participated in a modified Delphi process and the COS was finalised at a consensus meeting.\ud \ud Results:\ud Fifty participants rated the importance of each outcome. Sixty-six outcomes were included in Round 1 of the questionnaire; 13 outcomes were added by Round 1 participants and were rated in Round 2. Seventy-six percent of participants (n = 38) returned to Round 2 and 60 outcomes, including 4 outcomes added by participants in Round 1, received a rating of 7–9 by >70% and 1–3 by
Databáze:	OpenAIRE
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