Personalized risk prediction of postoperative cognitive impairment - rationale for the EU-funded BioCog project
| Autor: | Winterer, G, Androsova, G, Bender, O, Boraschi, D, Borchers, F, Dschietzig, TB, Feinkohl, I, Fletcher, Paul, Gallinat, J, Hadzidiakos, D, Haynes, JD, Heppner, F, Hetzer, S, Hendrikse, J, Ittermann, B, Kant, IMJ, Kraft, A, Krannich, A, Krause, R, Kühn, S, Lachmann, G, Van Montfort, SJT, Müller, A, Nürnberg, P, Ofosu, K, Pietsch, M, Pischon, T, Preller, J, Renzulli, E, Scheurer, K, Schneider, R, Slooter, AJC, Spies, C, Stamatakis, Emmanuel, Volk, HD, Weber, S, Wolf, A, Yürek, F, Zacharias, N, BioCog Consortium |
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| Přispěvatelé: | the BioCog consortium |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
BioCog consortium Multidisciplinaire généralités & autres [D99] [Sciences de la santé humaine] Neuroimaging Aging society Neuroimaging biomarkers Risk Assessment 03 medical and health sciences 0302 clinical medicine Postoperative Complications Risk Factors medicine media_common.cataloged_instance Humans Cognitive Dysfunction 030212 general & internal medicine European Union European union Cognitive impairment Intensive care medicine Postoperative cognitive dysfunction health care economics and organizations Multidisciplinary general & others [D99] [Human health sciences] media_common Molecular biomarkers business.industry Multivariate prediction algorithm Postoperative delirium Anesthésie & soins intensifs [D02] [Sciences de la santé humaine] medicine.disease Anesthesia & intensive care [D02] [Human health sciences] Biomarker (cell) Europe Psychiatry and Mental health Etiology business 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | info:eu-repo/grantAgreement/EC/FP7/602461 European Psychiatry European psychiatry (Online) 50 (2018): 34–39. doi:10.1016/j.eurpsy.2017.10.004 info:cnr-pdr/source/autori:Winterer, G., G. Androsova, O. Bender, D. Boraschi, F. Borchers, T. Dschietzig, I. Feinkohl, P. Fletcher, J. Gallinat, D. Hadzidiakos, J.D. Haynes, F. Heppner, S. Hetzer, J. Hendrikse, B. Ittermann, I.M.J. Kant, A. Kraft, A. Krannich, R. Krause, S. Kühn, S.J.T. van Montfort, A. Müller, P. Nürnberg, K. Ofosu, M. Pietzsch, T. Pischon, J. Preller, M. Renzulli, K. Scheurer, R. Schneider, A. Slooter, C. Spies, E. Stamatakis, H.D. Volk, S. Weber, A. Wolf, F. Yürek, N. Zacharias, the BioCog consortium./titolo:Personalized risk prediction of postoperative cognitive impairment-rationale for the EU-funded BioCog project./doi:10.1016%2Fj.eurpsy.2017.10.004/rivista:European psychiatry (Online)/anno:2018/pagina_da:34/pagina_a:39/intervallo_pagine:34–39/volume:50 European Psychiatry, 50, 34. Elsevier Masson |
| ISSN: | 0924-9338 |
| DOI: | 10.1016/j.eurpsy.2017.10.004 |
| Popis: | Postoperative cognitive impairment is among the most common medical complications associated with surgical interventions – particularly in elderly patients. In our aging society, it is an urgent medical need to determine preoperative individual risk prediction to allow more accurate cost–benefit decisions prior to elective surgeries. So far, risk prediction is mainly based on clinical parameters. However, these parameters only give a rough estimate of the individual risk. At present, there are no molecular or neuroimaging biomarkers available to improve risk prediction and little is known about the etiology and pathophysiology of this clinical condition. In this short review, we summarize the current state of knowledge and briefly present the recently started BioCog project (Biomarker Development for Postoperative Cognitive Impairment in the Elderly), which is funded by the European Union. It is the goal of this research and development (R&D) project, which involves academic and industry partners throughout Europe, to deliver a multivariate algorithm based on clinical assessments as well as molecular and neuroimaging biomarkers to overcome the currently unsatisfying situation. |
| Databáze: | OpenAIRE |
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