Inhibition of vertebrate telomerases by the triphosphate derivatives of some biologically active nucleosides
Autor: | Yuko Takayama, Toyofumi Yamaguchi, Hazuki Takahashi, Mineo Saneyoshi, Hiroshi Jinmei |
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Rok vydání: | 2003 |
Předmět: |
Guanine
Stereochemistry Deoxyribonucleotides Biochemistry chemistry.chemical_compound Genetics Moiety Animals Humans Nucleotide Enzyme Inhibitors Telomerase chemistry.chemical_classification Telomerase inhibition Nucleotides Guanine derivatives Biological activity General Medicine Thymine Kinetics chemistry Vertebrates Nucleic acid Molecular Medicine HeLa Cells |
Zdroj: | Nucleosides, nucleotidesnucleic acids. 22(5-8) |
ISSN: | 1525-7770 |
Popis: | In order to clarify the effect of the base moiety of nucleotide analogs on telomerase inhibition, triphosphate derivatives of biologically active nucleosides, 3′-azido-3′-deoxythymidine (AZT), 2′-deoxy-2′-fluoroarafuranosylthymine (FaraT), acycloguanosine (ACG) and their guanine or thymine counterparts (AZdG, FaraG and ACT, respectively) were investigated. In all of the present cases, guanine derivatives showed more potent inhibition than their thymine counterparts. |
Databáze: | OpenAIRE |
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