Inhibition of vertebrate telomerases by the triphosphate derivatives of some biologically active nucleosides

Autor: Yuko Takayama, Toyofumi Yamaguchi, Hazuki Takahashi, Mineo Saneyoshi, Hiroshi Jinmei
Rok vydání: 2003
Předmět:
Zdroj: Nucleosides, nucleotidesnucleic acids. 22(5-8)
ISSN: 1525-7770
Popis: In order to clarify the effect of the base moiety of nucleotide analogs on telomerase inhibition, triphosphate derivatives of biologically active nucleosides, 3′-azido-3′-deoxythymidine (AZT), 2′-deoxy-2′-fluoroarafuranosylthymine (FaraT), acycloguanosine (ACG) and their guanine or thymine counterparts (AZdG, FaraG and ACT, respectively) were investigated. In all of the present cases, guanine derivatives showed more potent inhibition than their thymine counterparts.
Databáze: OpenAIRE
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