Self-Assembling Peptide Artificial Enzyme as an Efficient Detection Prober and Inhibitor for Cancer Cells
| Autor: | Meiling Lian, Shuo Zhang, Jun Chen, Xuejiao Liu, Wensheng Yang, Xu Chen |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
biology
Artificial enzyme Biochemistry (medical) Biomedical Engineering General Chemistry equipment and supplies Cell biology Biomaterials chemistry.chemical_compound Ros scavenging chemistry Cancer cell polycyclic compounds biology.protein heterocyclic compounds Breast cancer cells Epithelial–mesenchymal transition Hemin Self-assembling peptide |
| Zdroj: | ACS applied bio materials. 2(5) |
| ISSN: | 2576-6422 |
| Popis: | A new hybrid nanoparticle (NP; fluorenylmethoxycarbonyl-arginine-glycine-aspartate and hemin, Fmoc-RGD/hemin NP) was developed for the simultaneous detection and inhibition of breast cancer cells. Hemin can regulate the reactive oxygen species (ROS), while Fmoc-RGD acts as a scaffold for hemin nanocrystallization. Fmoc groups interact with the porphyrin groups of hemin through hydrophobic and π-π interactions to form a hydrophobic core of the NPs. The hydrophilic RGD chains surround the core to maintain the stability of the nanoparticles in an aqueous medium. The RGD groups of Fmoc-RGD are also selective for tumor cells. This interaction can be exploited to enhance the selectivity of tumor detection. Based on enhanced peroxidase activity, Fmoc-RGD/hemin NPs were developed as signal transducers in a facile and fast point-of-care cancer diagnosis platform. This platform is sensitive to breast cancer cells and hydrogen peroxide (H |
| Databáze: | OpenAIRE |
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