A general synthetic approach to the amnesic shellfish toxins: total synthesis of (−)-isodomoic acid B, (−)-isodomoic acid E and (−)-isodomoic acid F
| Autor: | Simon Sedehizadeh, Nadia Fleary-Roberts, Gilles Lemière, Jonathan Clayden, Julie Toueg |
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| Rok vydání: | 2011 |
| Předmět: |
Models
Molecular Stereochemistry Alkyne Catalysis chemistry.chemical_compound Isomerism Amide Materials Chemistry medicine Organic chemistry Shellfish chemistry.chemical_classification Metals and Alloys Total synthesis General Chemistry medicine.disease Surfaces Coatings and Films Electronic Optical and Magnetic Materials Shellfish poisoning chemistry Cyclization Heptanoic Acids Isodomoic acid F Ceramics and Composites Isodomoic acid E Isodomoic acid B Marine Toxins |
| Zdroj: | Lemière, G, Sedehizadeh, S, Toueg, J, Fleary-Roberts, N & Clayden, J 2011, ' A general synthetic approach to the amnesic shellfish toxins: Total synthesis of (-)-isodomoic acid B, (-)-isodomoic acid E and (-)-isodomoic acid F ', Chemical Communications, vol. 47, no. 13, pp. 3745-3747 . https://doi.org/10.1039/c1cc00048a |
| ISSN: | 1364-548X 1359-7345 |
| Popis: | The alkynylpyrrolidine 4 was made via a dearomatising cyclisation of an aromatic amide, and was elaborated by stannylcupration and palladium-catalysed coupling to achieve the first total synthesis of three members of the isodomoic acid family; the same alkyne can be envisaged as a precursor to several more of this class of amnesic shellfish toxins. © The Royal Society of Chemistry. |
| Databáze: | OpenAIRE |
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