Marrow transplantation for aplastic anemia and acute leukemia
| Autor: | Paul E. Neiman, A Fefer, Glucksberg H, Lerner Kg, Buckner Cd, R Storb, Thomas Ed |
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| Rok vydání: | 1977 |
| Předmět: |
Graft Rejection
medicine.medical_specialty Cyclophosphamide medicine.drug_class Antibiotics Bone Marrow Cells Gastroenterology Graft vs Host Reaction Refractory Histocompatibility Antigens hemic and lymphatic diseases Internal medicine Intensive care Immune Tolerance medicine Humans Transplantation Homologous Aplastic anemia Bone Marrow Transplantation Acute leukemia Leukemia business.industry Immunologic Deficiency Syndromes Anemia Aplastic Total body irradiation medicine.disease surgical procedures operative Acute Disease Surgery Methotrexate business medicine.drug |
| Zdroj: | World Journal of Surgery. 1:197-204 |
| ISSN: | 1432-2323 0364-2313 |
| DOI: | 10.1007/bf01665082 |
| Popis: | Patients with severe aplastic anemia or refractory acute leukemia with HLA identical sibling donors were considered for marrow transplantation in Seattle. Patients with aplastic anemia were generally conditioned for grafting by high-dose cyclophosphamide (CY); those with acute leukemia by CY and total body irradiation. All patients received methotrexate post-grafting to ameliorate anticipated graft-versus-host disease (GVHD) and were supported with blood products, antibiotics, and intensive care as necessary. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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