Synthesis and antibiofilm evaluation of 3-hydroxy-2,3-dihydroquinazolin-4(1H)-one derivatives against opportunistic pathogen Acinetobacter baumannii
| Autor: | Guo-Bo Xu, Lei Tang, Guo Yang, Yuanyong Yang, Kim Lee Chua, Cheng Cheng |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Acinetobacter baumannii
Clinical Biochemistry Biofilm inhibition Pharmaceutical Science Drug resistance Biochemistry Microbiology Opportunistic pathogen Drug Discovery Humans Molecular Biology Quinazolinones biology Gentamycin sulphate Chemistry Organic Chemistry biochemical phenomena metabolism and nutrition biology.organism_classification Anti-Bacterial Agents Multiple drug resistance Quorum sensing Biofilms Molecular Medicine Autoinducer Acinetobacter Infections |
| Zdroj: | Bioorganic & Medicinal Chemistry. 28:115606 |
| ISSN: | 0968-0896 |
| Popis: | The emergence of multidrug resistant microorganisms has triggered the impending need for new aitimicrobial strategies. The antivirulence strategy with the benefite of alleviating the drug resistance becomes the focus of research. In this study, 22 quorum sensing inhibitors were synthesized by mimicking the structure of autoinducer and acinetobactin and up to 34% biofilm inhibition was observed with 5u. The biofilm inhibition effect was further demonstrated with extracellular polysaccharides inhibition and synergism with Gentamycin sulphate. |
| Databáze: | OpenAIRE |
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