Flow-mediated slowing of brachial-radial pulse wave velocity: Methodological aspects and clinical determinants

Autor: Fang-Fei Wei, Jan A. Staessen, Zhenyu Zhang, Nicholas Cauwenberghs, Yenthel Heyrman, Tatiana Kuznetsova, Wen-Yi Yang, Lutgarde Thijs
Rok vydání: 2018
Předmět:
medicine.medical_specialty
DILATION
Specialties of internal medicine
030204 cardiovascular system & hematology
Radial pulse
MECHANISMS
03 medical and health sciences
Hyperaemia
0302 clinical medicine
Internal medicine
Occlusion
medicine
Diseases of the circulatory (Cardiovascular) system
cardiovascular diseases
Pulse wave velocity
ARTERY
Science & Technology
NITRIC-OXIDE
HYPERTENSION
business.industry
Wave velocity
AMPLITUDE
HUMANS
General population
Endothelial function
Flow-mediated slowing
General Medicine
Stepwise regression
Peripheral Vascular Disease
HYPEREMIA
RC581-951
Ageing
RC666-701
ENDOTHELIAL DYSFUNCTION
Cuff
Cardiovascular System & Cardiology
cardiovascular system
Cardiology
medicine.symptom
business
Life Sciences & Biomedicine
030217 neurology & neurosurgery
VASODILATION
circulatory and respiratory physiology
Zdroj: Artery Research, Vol 21 (2018)
ISSN: 1876-4401
Popis: © 2017 Association for Research into Arterial Structure and Physiology Background Recent studies proposed that deceleration in pulse wave velocity (PWV) following reactive hyperaemia might reflect arterial distensibility and endothelial function. We therefore investigated methodological aspects and clinical determinants of new indexes of flow-mediated slowing (FMS) of PWV in a community-based sample. Methods In 71 subjects (mean age, 60.3 years; 50.7% women), we continuously assessed brachial-radial PWV using Vicorder® at baseline and after 3-min or 5-min suprasystolic upper-arm cuff occlusion. We calculated the relative change (Δ) in PWV per each 30 s intervals during 4 min of post-occlusion. We performed stepwise regression analyses to assess determinants of the PWV response. Results The peak FMS was detected at the first PWV recording obtained after occlusion. Overall, the decline in PWV during hyperaemia was significantly greater after 5-min of occlusion as compared to 3-min (effect sizes for 0–240 s intervals: −1.83% to −9.63%; P ≤ 0.037). PWV declined significantly less with higher age during the 0–60 s post-occlusion intervals (P ≤ 0.0053). On the other hand, after 120 s of post-occlusion, ΔPWV remained significantly lower in subjects with high diastolic blood pressure and oxidized LDL, and in smokers (P ≤ 0.028). Consequently, as compared to healthy reference group, participants with cardiovascular risk factors exhibited a delay in age-adjusted recovery of PWV after 5-min of occlusion (P ≤ 0.039). Conclusions Our findings confirm the use of a 5-min occlusion time for the assessment of vasomotor function by FMS. Whereas the early FMS response might deteriorate with ageing, cardiovascular risk factors such as smoking, oxidative stress and hypertension might affect recovery of PWV after reactive hyperaemia. ispartof: ARTERY RESEARCH vol:21 pages:29-37 status: published
Databáze: OpenAIRE
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