Tissue engineering scaffolds in the treatment of brain disorders in geriatric patients
| Autor: | Parisa Ghadiri Harati, Alireza Dehqan Niri, Ali Salimi, Ali Akbar Karimi Zarchi, Basil Mujokoro |
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| Rok vydání: | 2019 |
| Předmět: |
Scaffold
Aging Parkinson's disease 0206 medical engineering Biomedical Engineering Medicine (miscellaneous) Bioengineering Neural degeneration Biocompatible Materials 02 engineering and technology Disease 030204 cardiovascular system & hematology Regenerative Medicine Biomaterials 03 medical and health sciences 0302 clinical medicine Tissue engineering medicine Animals Humans Regeneration Brain Diseases Tissue Engineering Tissue Scaffolds business.industry Regeneration (biology) Brain General Medicine medicine.disease 020601 biomedical engineering Cancer cell Stem cell business Neuroscience |
| Zdroj: | Artificial organsREFERENCES. 43(10) |
| ISSN: | 1525-1594 |
| Popis: | The world population is ageing at an alarming rate, currently increasing at around 3% per year for people over 60 years. This fast growing demography is largely unproductive and prone to many brain disorders such as Alzheimer's disease, Parkinson's disease, and brain tumors. Currently available treatment modalities are inadequate to stop neural degeneration or to completely eradicate cancer cells. Exogenously engineered scaffolds hold great potential for in vivo brain regeneration and functional restoration. Ideally, scaffolds for brain tissue engineering should be biocompatible, non-toxic, and electroactive with the ability to encourage neural elongation. These scaffolds have been successfully fabricated from a wide range of materials and techniques. Different types of stem cells have also been investigated for their ability to differentiate to nerve or glial tissue. The success of tissue engineering can thus be envisioned as a panacea for "retooling" of both individual's ability and for immense long-term benefit of society. |
| Databáze: | OpenAIRE |
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