Synthesis of Deuterium-Labeled Derivatives of Dimethylallyl Diphosphate

Autor:	C. Dale Poulter, Hirekodathakallu V. Thulasiram, Susan B. Rivera, Richard M. Phan
Rok vydání:	2006
Předmět:	Hemiterpenes Organophosphorus Compounds Chemistry Extramural Stereochemistry Isotope Labeling Organic Chemistry Deuterium Deuterium labeled Chemical synthesis Article Enzymes
Zdroj:	The Journal of Organic Chemistry. 71:1739-1741
ISSN:	1520-6904 0022-3263
DOI:	10.1021/jo052384n
Popis:	Short practical syntheses for five deuterium labeled derivatives of dimethylallyl diphosphate (DMAPP) useful for enzymological studies are reported. These include the preparation of the C1-labeled derivatives (R)-[1-2H]3-methylbut-2-enyl diphosphate ((R)-[1-2H]1-OPP) and (S)-[1-2H]3-methylbut-2-enyl diphosphate ((S)-[1-2H]1-OPP), the C2-labeled derivative [2-2H]3-methylbut-2-enyl diphosphate ([2-2H]1-OPP), and the methyl-labeled derivatives (E)-[4,4,4-2H3]3-methylbut-2-enyl diphosphate ((E)-[4,4,4-2H3]1-OPP) and (Z)-[4,4,4-2H3]3-methyl-but-2-enyl diphosphate ((Z)-[4,4,4-2H3]1-OPP).
Databáze:	OpenAIRE
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