GABAergic inhibition gates excitatory LTP in perirhinal cortex
| Autor: | Vibhakar C. Kotak, Dan H. Sanes, Todd M. Mowery, Ana Mirallave |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cognitive Neuroscience Long-Term Potentiation Hippocampus GABAB receptor Bicuculline Article GABA Antagonists Tissue Culture Techniques 03 medical and health sciences 0302 clinical medicine Slice preparation Receptors GABA Perirhinal cortex medicine Animals Perirhinal Cortex Neurons Chemistry GABAA receptor musculoskeletal neural and ocular physiology Excitatory Postsynaptic Potentials Long-term potentiation Neural Inhibition Electric Stimulation 030104 developmental biology medicine.anatomical_structure nervous system Excitatory postsynaptic potential Gerbillinae Neuroscience Microelectrodes 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Hippocampus. 27(12) |
| ISSN: | 1098-1063 |
| Popis: | The perirhinal cortex (PRh) is a key region downstream of auditory cortex (ACx) that processes familiarity linked mnemonic signaling. In gerbils, ACx-driven EPSPs recorded in PRh neurons are largely shunted by GABAergic inhibition (Kotak et al., 2015, Frontiers in Neural Circuits, 9). To determine whether inhibitory shunting prevents the induction of excitatory long-term potentiation (e-LTP), we stimulated ACx-recipient PRh in a brain slice preparation using theta burst stimulation (TBS). Under control conditions, without GABA blockers, the majority of PRh neurons exhibited long-term depression. A very low concentration of bicuculline increased EPSP amplitude, but under this condition TBS did not significantly increase e-LTP induction. Since PRh synaptic inhibition included a GABAB receptor-mediated component, we added a GABAB receptor antagonist. When both GABAA and GABAB receptors were blocked, TBS reliably induced e-LTP in a majority of PRh neurons. We conclude that GABAergic transmission is a vital mechanism regulating e-LTP induction in the PRh, and may be associated with auditory learning. |
| Databáze: | OpenAIRE |
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