Social touch promotes interfemale communication via activation of parvocellular oxytocin neurons
| Autor: | Angel Baudon, Ranjan K. Roy, Daisuke Hagiwara, Diego Benusiglio, Louis Hilfiger, Gareth Leng, Pascal Darbon, Karl Kklaus Conzelmann, Arthur Lefevre, Shlomo Wagner, Jonas Schimmer, Shiyi Wang, Yan Tang, Ferdinand Althammer, Valery Grinevich, Martin K. Schwarz, Matthew K. Kirchner, Inga D. Neumann, Marina Eliava, Anna Bludau, Alexandre Charlet, Javier E. Stern, Martina Oberhuber |
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| Přispěvatelé: | Institut des Neurosciences Cellulaires et Intégratives (INCI), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
genetic structures Population Biology Oxytocin Synapse 03 medical and health sciences 0302 clinical medicine Parvocellular cell medicine Animals Rats Wistar education Social Behavior Neurons education.field_of_study Behavior Animal General Neuroscience [SCCO.NEUR]Cognitive science/Neuroscience Rats 030104 developmental biology medicine.anatomical_structure nervous system Touch Perception Touch Forebrain Magnocellular cell [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Female Neuron sense organs Neuroscience hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery Social behavior medicine.drug Paraventricular Hypothalamic Nucleus |
| Zdroj: | Nature Neuroscience Nature Neuroscience, Nature Publishing Group, 2020, 23 (9), pp.1125-1137. ⟨10.1038/s41593-020-0674-y⟩ |
| ISSN: | 1546-1726 1097-6256 |
| DOI: | 10.1038/s41593-020-0674-y⟩ |
| Popis: | Oxytocin (OT) is a great facilitator of social life but, although its effects on socially relevant brain regions have been extensively studied, OT neuron activity during actual social interactions remains unexplored. Most OT neurons are magnocellular neurons, which simultaneously project to the pituitary and forebrain regions involved in social behaviors. In the present study, we show that a much smaller population of OT neurons, parvocellular neurons that do not project to the pituitary but synapse onto magnocellular neurons, is preferentially activated by somatosensory stimuli. This activation is transmitted to the larger population of magnocellular neurons, which consequently show coordinated increases in their activity during social interactions between virgin female rats. Selectively activating these parvocellular neurons promotes social motivation, whereas inhibiting them reduces social interactions. Thus, parvocellular OT neurons receive particular inputs to control social behavior by coordinating the responses of the much larger population of magnocellular OT neurons. Charlet, Grinevich et al. show that social touch between female rats activates parvocellular oxytocin neurons; these neurons control social behavior by coordinating the responses of the much larger population of magnocellular oxytocin neurons. |
| Databáze: | OpenAIRE |
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