Differences in IgG Antibody Responses following BNT162b2 and mRNA-1273 SARS-CoV-2 Vaccines
| Autor: | Sien Deng, Amy E Adams, Martina Li, Valerie Bonetti, Dominick L. Frosch, Kjerstie Olson, Ellis C Dillon, Nan A Link, Suzanne Pertsch, Jose G. Montoya |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Time Factors Physiology Antibodies Viral Serology Cohort Studies mRNA-1273 Immunogenicity Vaccine vaccine Medicine antibodies Prospective Studies Ecology biology Vaccination vaccines Middle Aged QR1-502 Titer Infectious Diseases Spike Glycoprotein Coronavirus Female mRNA Vaccines Antibody Research Article 2019-nCoV Vaccine mRNA-1273 Microbiology (medical) Adult COVID-19 Vaccines IgG Microbiology Virus Immune system Genetics Humans Clinical significance BNT162 Vaccine Aged General Immunology and Microbiology business.industry SARS-CoV-2 COVID-19 Cell Biology Immunization Immunoglobulin G Immunology Antibody Formation biology.protein BNT162b2 business |
| Zdroj: | Microbiology Spectrum, Vol 9, Iss 3 (2021) Microbiology Spectrum |
| ISSN: | 2165-0497 |
| Popis: | Studies examining antibody responses by vaccine brand are lacking and may be informative for optimizing vaccine selection, dosage, and regimens. The purpose of this study is to assess IgG antibody responses following immunization with BNT162b2 (30 μg mRNA) and mRNA-1273 (100 μg mRNA) vaccines. A cohort of clinicians at a nonprofit organization is being assessed clinically and serologically following immunization with BNT162b2 or mRNA-1273. IgG responses were measured at the Remington Laboratory by an IgG assay against the SARS-CoV-2 spike protein-receptor binding domain. Mixed-effect linear (MEL) regression modeling was used to examine whether the SARS-CoV-2 IgG level differed by vaccine brand, dosage, or number of days since vaccination. Among 532 SARS-CoV-2 seronegative participants, 530 (99.6%) seroconverted with either vaccine. After adjustments for age and gender, MEL regression modeling revealed that the average IgG antibody level increased after the second dose compared to the first dose (P |
| Databáze: | OpenAIRE |
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