From the epididymis to the egg: participation of CRISP proteins in mammalian fertilization
Autor: | Cohen Db, Patricia S. Cuasnicú, Mariana Weigel Muñoz, Ludmila Curci, Nicolás Gastón Brukman, Da Ros Vg, Maria A. Battistone, Gómez-ElIas, Guillermo Carvajal |
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Jazyk: | angličtina |
Rok vydání: | 2015 |
Předmět: |
Infertility
Male Urology EPIDIDYMAL PROTEINS Biology lcsh:RC870-923 Cysteine-RIch Secretory Proteins epididymal proteins fertilization sperm purl.org/becyt/ford/1 [https] Ciencias Biológicas Human fertilization Capacitation FERTILIZATION medicine Animals Humans purl.org/becyt/ford/1.6 [https] Epididymis Sperm-Ovum Interactions Membrane Glycoproteins Invited Review General Medicine Anatomy CRISP lcsh:Diseases of the genitourinary system. Urology medicine.disease Sperm Spermatozoa Cell biology Secretory protein medicine.anatomical_structure Gamete Female Signal transduction Biología Reproductiva Sperm Capacitation CIENCIAS NATURALES Y EXACTAS SPERM |
Zdroj: | Asian Journal of Andrology CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET Asian Journal of Andrology, Vol 17, Iss 5, Pp 711-715 (2015) |
Popis: | Mammalian fertilization is a complex process that involves different steps of interaction between the male and female gametes. In spite of its relevance, the molecular mechanisms underlying this process still remain to be elucidated. The present review describes the contribution of our laboratory to the understanding of mammalian fertilization by using CRISP (Cysteine-RIch Secretory Proteins) as model molecules. Substantial evidence obtained using in vitro assays and knockout models shows that epididymal CRISP1 associates with the sperm surface with two different affinities during maturation and participates in the regulation of signaling pathways during capacitation as well as in both sperm-zona pellucida interaction and gamete fusion. These observations can be extended to humans as judged by our findings showing that the human homologue of the rodent protein (hCRISP1) is also involved in both stages of fertilization. Evidence supports that other members of the CRISP family secreted in the testes (CRISP2), epididymis (CRISP3-4) or during ejaculation (CRISP3) are also involved in sperm-egg interaction, supporting the existence of a functional redundancy and cooperation between homologue proteins to ensure the success of fertilization. Together, our observations indicate that CRISP proteins escort sperm along their transit through both the male and female reproductive tracts. We believe these results not only contribute to a better mechanistic understanding of fertilization but also support CRISP proteins as excellent candidates for future research on infertility and contraception. Fil: Da Ros, Vanina Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina Fil: Weigel Muñoz, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina Fil: Battistone, Maria Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina Fil: Brukman, Nicolás Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina Fil: Carvajal, Guillermo. Fundacion de Instituto de Biologia y Medicina Experimental; Argentina Fil: Curci, Ludmila. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina Fil: Gómez Elías, Matías Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina Fil: Cohen, Debora Juana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina Fil: Cuasnicu, Patricia Sara. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina |
Databáze: | OpenAIRE |
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