Fluorescent sensing of monofunctional platinum species
| Autor: | Elizabeth J. New, Kellie A. Charles, Lucy J. Dawson, Benjamin D. W. Harris, Clara Shen, Trevor W. Hambley |
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| Rok vydání: | 2015 |
| Předmět: |
Organoplatinum Compounds
Chemistry Metals and Alloys chemistry.chemical_element General Chemistry Photochemistry Fluorescence Catalysis Chemistry Techniques Analytical Surfaces Coatings and Films Electronic Optical and Magnetic Materials chemistry.chemical_compound Spectrometry Fluorescence Materials Chemistry Ceramics and Composites Humans Fluorescein Caco-2 Cells Platinum Fluorescent Dyes |
| Zdroj: | Chemical communications (Cambridge, England). 51(29) |
| ISSN: | 1364-548X |
| Popis: | We report here FDCPt1, a novel selective fluorescent sensor for monofunctional platinum species. In the presence of such species, FDCPt1 exhibits a 70-fold increase in fluorescence emission, and can be used to monitor the metabolism of Pt(II)-based complexes in colorectal cancer cells. This probe is therefore expected to be valuable in studying changes in Pt coordination and distribution during chemotherapy. |
| Databáze: | OpenAIRE |
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