Lineage-dependent circuit assembly in the neocortex

Autor:	Khadeejah T. Sultan, Xin-Jun Zhang, Peng Gao, Song-Hai Shi
Rok vydání:	2013
Předmět:	Neurons Neocortex Lineage (genetic) Neurogenesis Neuronal migration Review Anatomy Biology medicine.anatomical_structure Neuronal circuits Cell Movement medicine Biological neural network Animals Humans Molecular Biology Neuroscience Developmental Biology
Zdroj:	Development. 140:2645-2655
ISSN:	1477-9129 0950-1991
DOI:	10.1242/dev.087668
Popis:	The neocortex plays a key role in higher-order brain functions, such as perception, language and decision-making. Since the groundbreaking work of Ramón y Cajal over a century ago, defining the neural circuits underlying brain functions has been a field of intense study. Here, we review recent findings on the formation of neocortical circuits, which have taken advantage of improvements to mouse genetics and circuit-mapping tools. These findings are beginning to reveal how individual components of circuits are generated and assembled during development, and how early developmental processes, such as neurogenesis and neuronal migration, guide precise circuit assembly.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::820f1e98f786338ac32ce71cb65a3bed https://doi.org/10.1242/dev.087668 Zobrazit plný text záznamu