Estrogen and Myc negatively regulate expression of the EphA2 tyrosine kinase
| Autor: | Michael S. Kinch, Nicole D. Zantek, Elizabeth J. Taparowsky, Daniel P. Zelinski, Mette A. Peters, Jennifer Walker-Daniels |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Neoplasms
Hormone-Dependent medicine.drug_class Estrogen receptor Breast Neoplasms Disease Biology Biochemistry Gene Expression Regulation Enzymologic Metastasis Cell Line Proto-Oncogene Proteins c-myc Breast cancer medicine Tumor Cells Cultured Humans Breast RNA Messenger RNA Neoplasm Molecular Biology Estrogen receptor beta Estradiol Receptor EphA2 Receptor Protein-Tyrosine Kinases Epithelial Cells Estrogens Cell Biology medicine.disease EPH receptor A2 Gene Expression Regulation Neoplastic Receptors Estrogen Estrogen Cancer research Female Estrogen receptor alpha |
| Zdroj: | Journal of cellular biochemistry. 85(4) |
| ISSN: | 0730-2312 |
| Popis: | Estrogen receptor and c-Myc are frequently overexpressed during breast cancer progression but are downregulated in many aggressive forms of the disease. High levels of the EphA2 tyrosine kinase are consistently found in the most aggressive breast cancer cells, and EphA2 overexpression can increase metastatic potential. We demonstrate, herein, that estrogen and Myc negatively regulate EphA2 expression in mammary epithelial cells. These data reveal EphA2 as a downstream target of estrogen and Myc and suggest a mechanism by which estrogen and Myc may regulate breast cancer. |
| Databáze: | OpenAIRE |
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