Association of adult attention deficit hyperactivity disorder subtypes and response to methylphenidate HCL treatment: A magnetic resonance spectroscopy study
| Autor: | Yilmaz Kiroglu, Ayse Nur Inci Kenar, Hasan Herken, G.A. Unal |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Magnetic Resonance Spectroscopy Subtype methylphenidate Striatum Choline chemistry.chemical_compound N-acetylaspartate analogs and derivatives Adult ADHD Cerebellum middle aged central stimulant agent Prefrontal cortex dorsolateral prefrontal cortex prefrontal cortex Methylphenidate General Neuroscience adult cingulate gyrus drug effect medicine.anatomical_structure female priority journal nuclear magnetic resonance scanner young adult Psychology medicine.drug medicine.medical_specialty Adolescent metabolite attention deficit disorder Creatine Gyrus Cinguli Article Internal medicine mental disorders medicine Attention deficit hyperactivity disorder Humans human corpus striatum Anterior cingulate cortex nuclear magnetic resonance spectroscopy anterior cingulate Aspartic Acid n acetylaspartic acid treatment response medicine.disease major clinical study Dorsolateral prefrontal cortex Endocrinology chemistry Attention Deficit Disorder with Hyperactivity Central Nervous System Stimulants Neuroscience human activities metabolism |
| Popis: | The effects of methylphenidate (MPH) treatment on N-acetyl aspartate (NAA), choline and creatine are being examined in individuals with different subtypes of attention deficit hyperactivity disorder (ADHD). Sixty ADHD subjects were included into the study aging between 18 and 60 years. Levels of NAA, creatine and choline in anterior cingulate cortex, cerebellum, striatum and dorsolateral prefrontal cortex were measured with magnetic resonance spectroscopy. Then, 10 mg oral MPH was given to the subjects and the same metabolite levels were measured after an interval of 30 min. Distribution of the patients according to the ADHD subtypes was as follows: 21 of them (35.0%) were in the inattentive type, 11 of them (18.3%) were in the hyperactive type and 28 of them were (46.7%) in the combined type. Changes of brain metabolite levels after MPH were found not to be statistically significantly different between the subtypes. The increase of choline levels after MPH compared to the levels of choline before MPH in striatum in the combined type patients were statistically significant. No clear association was found between ADHD subtypes and changes of brain metabolites with use of MPH in adult ADHD. © 2015 Elsevier Ireland Ltd. |
| Databáze: | OpenAIRE |
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