Herbal management of hepatocellular carcinoma through cutting the pathways of the common risk factors

Autor: Ahmed Abdelnaser mohamed, Daniah AL-jader, Amal Mohamed, Nabil Abdel-Hamid, Shimaa Abass
Rok vydání: 2018
Předmět:
Zdroj: Biomedicine & Pharmacotherapy
ISSN: 0753-3322
DOI: 10.1016/j.biopha.2018.08.104
Popis: Graphical abstract
Highlights • Certainly, hepatocellular carcinoma is an end station to common risk factors, found in the exposed persons with different degrees, these, collectively, determine both the onset and margin of his life. • Nutrition and dietary life style, contribute with a great value in alleviating or exaggerating the severity of viral hepatic infection outcomes. • Chronic, non treated HCV, HBV infections, NAFLD, oxidative stress, inborn metabolic errors and environmental toxins are the major contributors for HCC. • Endemic herbals, like, Wolfberry, green tea, red grapes, curcuma and allied rhizomes like Coptidis, Alpinia officinarum, Ginger and Glycyrrhiza glabra, as well as Broccoli sprouts, Andrographis paniculata, Silybum marianum, Nigella sativa and Illicium verum, are examples of these plants having specific biodrugs that can cut the pathways between the aforementioned risk factors and HCC development, or at least slow down reaching this fate.
Hepatocellular carcinoma (HCC) is considered the most frequent tumor that associated with high mortality rate. Several risk factors contribute to the pathogenesis of HCC, such as chronic persistent infection with hepatitis C virus or hepatitis B virus, chronic untreated inflammation of liver with different etiology, oxidative stress and fatty liver disease. Several treatment protocols are used in the treatment of HCC but they also associated with diverse side effects. Many natural products are helpful in the co-treatment and prevention of HCC. Several mechanisms are involved in the action of these herbal products and their bioactive compounds in the prevention and co-treatment of HCC. They can inhibit the liver cancer development and progression in several ways as protecting against liver carcinogens, enhancing effects of chemotherapeutic drugs, inhibiting tumor cell growth and metastasis, and suppression of oxidative stress and chronic inflammation. In this review, we will discuss the utility of diverse natural products in the prevention and co-treatment of HCC, through its capturing of the common risk factors known to lead to HCC and shed the light on their possible mechanisms of action. Our theory assumes that shutting down the risk factor to cancer development pathways is a critical strategy in cancer prevention and management. We recommend the use of these plants side by side to recent chemical medications and after stopping these chemicals, as a maintenance therapy to avoid HCC progression and decrease its global incidence.
Databáze: OpenAIRE
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